| 炙甘草汤主要有效成分对心肌生理特性的影响 |
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| 引用本文： | 陈兰英,陈奇,刘荣华,毕明,周丽娟,李文宏.炙甘草汤主要有效成分对心肌生理特性的影响[J].中草药,2001,32(2):134-135. |
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| 作者姓名： | 陈兰英 陈奇 刘荣华 毕明 周丽娟 李文宏 |
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| 作者单位： | 江西中医学院，江西南昌 330006 |
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| 基金项目： | 国家自然科学基金资助项目(39860084)，江西省自然科学基金资助项目(94535) |
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| 摘 要： | 目的：观察炙甘草汤主要有效成分及部位对大鼠离体心肌生理特性的影响。方法：采用大鼠离体心房肌和心乳头肌，研究药物对心肌自律性，心奋性和功能不应期的作用。结果甘草酸、人参总皂苷和麦冬总皂苷合用能明显降低大离体左心房肌自律性和左心房肌心奋性，明显延长大鼠离体左心房肌功能不应期，明显抑制肾上腺素诱发大鼠离体乳头状肌自律性和心律失常，而缺少这３种成分的炙甘草汤作用明显低于炙甘草汤全方。结论甘草酸，人参总皂苷和麦冬总苷为炙甘草汤中抗心律失常的主要有效成分及部位。
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| 关 键 词： | 炙甘草汤 甘草酸 人参总皂苷 麦冬总皂苷 心肌生理特性 中药 心肌疾病 有效成分 |
| 文章编号： | 0253-2670(2001)02-0134-03 |
| 收稿时间： | 2000/4/18 0:00:00 |
| 修稿时间： | 2000年4月18日 |
Studies on effect of main active principles in ZHIGANCAO DE COCTION on myocardial electrophysiology |
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| CHEN Lan ying,CHEN Qi,LIU Rong hu,BI Ming,ZHOU Li juan and LI Wen hong.Studies on effect of main active principles in ZHIGANCAO DE COCTION on myocardial electrophysiology[J].Chinese Traditional and Herbal Drugs,2001,32(2):134-135. |
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| Authors: | CHEN Lan ying CHEN Qi LIU Rong hu BI Ming ZHOU Li juan and LI Wen hong |
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| Institution: | Jiangxi College of TCM, Nanchang Jiangxi 330006, China;Jiangxi College of TCM, Nanchang Jiangxi 330006, China;Jiangxi College of TCM, Nanchang Jiangxi 330006, China;Jiangxi College of TCM, Nanchang Jiangxi 330006, China;Jiangxi College of TCM, Nanchang Jiangxi 330006, China;Jiangxi College of TCM, Nanchang Jiangxi 330006, China |
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| Abstract: | Object To study the influence of main active principles of ZHIGANCAO DECOCTIDN (ZD), glycyrrhizic acid (GA), ginseng total saponin (GTS) and Ophiopogon total saponin (OTS) on electrophysiology of isolated rat myocardium Methods The influence of GA, GTS and OTS on the automaticity, excitability and functional refractory period of isolated rat atrium and papillary muscle were studied in comparison with ZD made free of the above said active ingredients Results The combine use of GA, GTS and OTS significantly decreased the automaticity, inhibited excitaibility and prolonged the functional refractory period of isolated rat atrium; decreased the automaticity and arrhythmia of papillary muscle induced by epinephrine, while ZD made free of GS, GTS and OTS showed much less effect than the intact decoction Conclusion GA, GTS and OTS proved to be the main effective ingredients responsible for the antiarrhythmic activity of ZD |
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| Keywords: | ZHIGANCAO DECOCTION glycyrrhizic acid (GA) ginseng total saponin (GTS) Ophiopogon total saponin (OTS) myocardial electrophysiological characteristics |
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