Comparative study on three chemotherapeutic regimens for the treatment of advanced epithelial ovarian cancer

To investigate the best first-line chemotherapy regimen for the treatment of advanced ep- ithelial ovarian cancer (AEOC), the efficacy of three chemotherapy regimens for treatment of the pa- tients with AEOC in our hospital during Jan. 1992- Jan. 1999 was retrospectively analyzed. The therapeutic effects were compared with the supplement of Melphalan Hexamethylme (PAM HMM), cisplatin adriamycin cyclophosphamide or isofamide (PAC) or cisplatin cyclophospha- mide or isofamide (PC), Taxol cisplatin (TP) combined chemotherapy after cytoreductive surgery. The results showed that the overall effective rate of TP was significantly higher than that of PAM HMM (P<0. 05); The complete remission rate of TP was significantly higher than that of PAM HMM and PAC or PC (all P<0. 05); The 2-year survival rate free of tumor of TP was obviously higher than that of PAM HMM and PAC or PC(all P<0. 05). It was concluded that the therapeu- tic effect of TP regimen in the treatment of AEOC was better than PAM HMM and PAC or PC and TP regimen could be recommended currently as the preferred first-line one for the treatment of AEOC.