The role of protein kinase C and its effect on GHRH in the regulation of hormone secretion by somatotrophinomas |
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Authors: | Liu Kui Liu Qin Bai Xiangjun Lei Ting Xue Delin |
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Institution: | 1. Department of Neurosurgery, Tongji Hospital, Tongji Medical University, Wuhan 430030 2. Department of Pediatrics, Xiehe Hospital, Tongji Medical University, Wuhan 430022 |
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Abstract: | Summary: Phorbol ester-induced release of growth hormone (GH) and prolactin (PRL) from hu- man somatotrophic tumors was examined in vitro. 12-O-tetradecanoyl-phorbol-13-acetate (TPA) strongly stimulated GH and PRL secretion and showed an additive effect on GH secretion if used in combination with GH releasing hormone (GHRH). In contrast, staurosporine exerted a variable inhibitory effect on GH release. There was no correlation between such effects and gsp mutations. The findings suggested that TPA doesn't act directly through cAMP signal transduction system. |
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Keywords: | somatotrophinoma phorbol ester growth hormone releasing hormone signal transduction |
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