L-carnitine supplementation,caffeine and fuel oxidation in the exercising rat |
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| Affiliation: | 1. Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia;2. Environment and Biomaterial Unit, Health Sciences Research Center, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia;3. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia;4. Department of Basic Health Sciences, Preparatory Year, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia;5. Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;1. College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China;2. National School of Development, Peking University, Beijing 100871, China |
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| Abstract: | The effect of L-carnitine (L-C) supplementation on carnitine status and on the reduction of muscle energy stores during exercise was investigated in the rat. L-C was supplied in the feed (5mg/kg) of trained, male Sprague Dawley rats for 10 days. After supplementation, the concentration of L-C in blood and muscles increased markedly (blood free L-C from 23 to 99 μmol/l, p<0.001; quadriceps, soleus and gluteus muscles, between +36% and +77%, p<0.001). The decrease of total L-C in muscles upon 40 minutes of treadmill running (between −15% and −29% p<0.001) was prevented by this supplementation. Glycogen decrements in both red muscles following exercise were similar either with or without L-C (between −70% and −84%, p<0.01). Intragastric administration of caffeine (15mg/kg) prior to exercise had no effect on circulating fatty acids, increased the mobilization of triglycerides from the quadriceps (p<0.01), but produced no synergistic effect with L-C on the amount of substrates used. |
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