Dietary carbohydrate stimulates alcohol diet ingestion,promotes growth and prevents fatty liver in rats |
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| Affiliation: | 1. Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA;2. Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, NCTR-53C RM204L HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA;3. Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA;4. Biostatistics Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop A3-03, Research Triangle Park, NC 27709, USA;5. Social & Scientific Systems, Inc., 1009 Slater Rd # 120, Durham, NC 27703, USA;6. National Cancer Institute, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop B2-01, Research Triangle Park, NC 27709, USA;1. Department of Internal Medicine, University of Iowa, Iowa City, IA, USA;2. Department of Epidemiology, University of Iowa, Iowa City, IA, USA;3. Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA, USA;4. Department of Psychiatry and the Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA |
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| Abstract: | When young male Sprague Dawley rats were fed ad libitum for 4 weeks a Lieber-DeCarli diet containing 36% of the total calories as ethanol, they consumed ca 50 ml of diet per day, gained 3–3.7 g/day and their livers contained ca 60 mg triglyceride/g. On the other hand, when rats were maintained on isocaloric diets containing 30%, 26% or 20% of calories as alcohol, the daily diet consumption (64, 67 and 88 ml respectively) and growth rate (4.2, 5.8 and 6.9 g respectively) increased markedly and their livers contained only 20–25 mg triglyceride/g. The amount of alcohol calories consumed per day or the alcohol consumption per 100 g body weight were comparable in the various diet groups. Since the reduction in alcohol calories was compensated for by including isocaloric amounts of maltose-dextrins, it is likely that the increased carbohydrate content stimulated diet ingestion, promoted growth and prevented the development of fatty liver despite chronic alcohol consumption. |
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