Effect of calcium phosphate supplementation on blood pressure in the wistar rat |
| |
| Affiliation: | 1. Division of Nutritional Sciences UCLA School of Public Health Los Angeles, CA 90024 USA;2. Calreco, Inc. Van Nuys, CA 91412 USA;1. Department of Biochemistry, Faculty of Science, Alexandria University, Egypt;2. Department of Medical Biotechnology, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technology Applications (SRTA-City), New Borg EL-Arab 21934, Alexandria, Egypt;3. Department of Pesticide Chemistry and Technology, Faculty of Agriculture, 21545-El-Shatby, Alexandria University, Alexandria, Egypt;1. Institute of Food Science, Zhejiang-Russia Joint R&D Center for Nutritional and Health Foods'' Green Manufacturing, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, PR China;2. College of Standardization, China Jiliang University, Hangzhou, Zhejiang 310018, PR China;3. Department of Food Science and Technology, The University of Georgia, Athens, GA 30602, USA;4. College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China;5. Zhejiang Provincial Key Laboratory of Integration of Healthy Smart Kitchen System, Fotile Group, Ningbo, Zhejiang 315336, PR China |
| |
| Abstract: | Normal rats reared on a Chow® diet supplemented with high levels of Ca generally have lower systolic blood pressure (SBP) at maturity. In order to determine the minimum level of dietary Ca required for this effect, we evaluated the results on SBP in the Wistar rat of supplementing the AIN-76 diet with various amounts of CaHPO4. Four groups of nine five-week old male Wistar rats were fed ad libitum for 12 weeks the AIN-76 semi-purified diet either unsupplemented (0.5% Ca, control diet) or supplemented to 1.0% (Diet A), 1.4% (Diet B), or 2.2% Ca (Diet C) with CaHPO4. A similar group of five rats was fed Rat Chow® ad libitum. Food consumption and growth rates were similar in all groups consuming the defined diets. SBP was measured indirectly by the tail cuff method biweekly for nine weeks and weekly thereafter. Analysis of variance by repeated measures indicated a significant effect of CaHPO4 supplementation upon SBP. The weekly mean SBP differed only at the 12th week. Pooled SBP data from groups eating Diets B and C were significantly lower than those of other groups on four of the seven occasions on which blood pressure measurements were taken after the rats had attained their adult SBP levels. The data indicate that Ca supplementation exerts a hypotensive effect at relatively low levels and that this effect is not dependent upon depletion of body PO4 |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
