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| Genetic diversity of the hepatitis C virus： Impact and issues in the antiviral therapy | |
| 引用本文： | Le Guillou-Guillemette H,Vallet S,Gaudy-Graffin C,Payan C,Pivert A,Goudeau A,Lunel-Fabiani F. Genetic diversity of the hepatitis C virus： Impact and issues in the antiviral therapy[J]. World journal of gastroenterology : WJG, 2007, 13(17): 2416-2426. DOI: 10.3748/wjg.v13.i17.2416 |
| 作者姓名： | Le Guillou-Guillemette H Vallet S Gaudy-Graffin C Payan C Pivert A Goudeau A Lunel-Fabiani F |
| 作者单位： | Laboratory of Virology University Hospital of Angers France and Laboratory HIFI UPRES EA 3859 University of Angers France,Department of Microbiology EA 3882 CHU Morvan University Hospital of Brest France,Université Francois Rabelais INSERM ERI 19 et CHRU de Tours Tours France,Department of Microbiology EA 3882 CHU Morvan University Hospital of Brest France,Laboratory of Virology University Hospital of Angers France and Laboratory HIFI UPRES EA 3859 University of Angers France,Université Francois Rabelais INSERM ERI 19 et CHRU de Tours Tours France,Laboratory of Virology University Hospital of Angers France and Laboratory HIFI UPRES EA 3859 University of Angers France |
| 摘 要： | The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. |
| 关 键 词： | 丙型肝炎病毒 基因多态性 抗病毒治疗 NS3 NS5A NS5B E2基因 |
| 收稿时间： | 2006-12-23 |
Genetic diversity of the hepatitis C virus: impact and issues in the antiviral therapy |
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| Le Guillou-Guillemette H,Vallet S,Gaudy-Graffin C,Payan C,Pivert A,Goudeau A,Lunel-Fabiani F. Genetic diversity of the hepatitis C virus: impact and issues in the antiviral therapy[J]. World journal of gastroenterology : WJG, 2007, 13(17): 2416-2426. DOI: 10.3748/wjg.v13.i17.2416 | |
| Authors: | Le Guillou-Guillemette H Vallet S Gaudy-Graffin C Payan C Pivert A Goudeau A Lunel-Fabiani F |
| Affiliation: | 1. Laboratory of Virology, University Hospital of Angers, France and Laboratory HIFI, UPRES EA 3859, University of Angers, France 2. Department of Microbiology, EA 3882, CHU Morvan, University Hospital of Brest, France 3. Université Francois Rabelais,INSERM ERI 19 et CHRU de Tours, Tours, France |
| Abstract: | The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. |
| Keywords: | Hepatitis C virus Genetic diversity Therapy resistance E2 NS3 NS5A NS5B |
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