| 旋磁场对癫痫大鼠模型的影响 |
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| 引用本文： | 苗玲,沈沸,苏敏,张毅,全海曦,蔡琰. 旋磁场对癫痫大鼠模型的影响[J]. 上海交通大学学报(医学版), 2005, 25(6): 565-568 |
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| 作者姓名： | 苗玲 沈沸 苏敏 张毅 全海曦 蔡琰 |
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| 作者单位： | 上海第二医科大学仁济医院神经内科，上海第二医科大学仁济医院神经内科，上海第二医科大学仁济医院神经内科，上海第二医科大学仁济医院神经内科，上海交通大学海洋水下工程科学研究院，上海第二医科大学仁济医院神经内科 上海200001，上海200001，上海200001，上海200001，上海200001 |
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| 摘 要： | 目的观察旋磁场对癫痫发作的影响。方法用20mT旋磁场分别作用于海人藻酸致痫后的大鼠模型和磁疗后3～8d的氯化锂—匹鲁卡品癫痫大鼠模型,观察癫痫发作程度、潜伏期和终止时间。结果前者发作潜伏期明显延长,发作程度明显减轻;后者长疗程磁场组发作终止时间提前,与对照组和短疗程磁场组相比有显著性差异(P<0.05)。结论20mT旋磁场对大鼠癫痫发作有一定抑制作用。
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| 关 键 词： | 大鼠模型 旋磁场 癫痫发作 发作程度 显著性差异 匹鲁卡品 海人藻酸 抑制作用 潜伏期 氯化锂 长疗程 短疗程 对照组 时间 |
| 文章编号： | 0258-5898(2005)06-0565-04 |
| 修稿时间： | 2004-03-22 |
Effect of Rotational Magnetic Field on Epileptic Rat Model |
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| MIAO Ling ,SHEN Fei ,SU Min ,ZHANG Yi ,QUAN Hai-xi ,CAI Yan. Effect of Rotational Magnetic Field on Epileptic Rat Model[J]. Journal of Shanghai Jiaotong University:Medical Science, 2005, 25(6): 565-568 |
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| Authors: | MIAO Ling SHEN Fei SU Min ZHANG Yi QUAN Hai-xi CAI Yan |
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| Affiliation: | MIAO Ling 1,SHEN Fei 1,SU Min 1,ZHANG Yi 1,QUAN Hai-xi 2,CAI Yan 1 |
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| Abstract: | Objective To observe the effect of rotational magnetic field on seizure activity. Methods The rats with kainic acid (KA)-induced seizure were subject rotational magnetic field of 20 mT immediately. The rest of the rats were exposed to the same magnetic field for 3~8 d first, then the li-pilocarpine-induced seizure models were established. We observed the severity and latency of seizure, and the time period of epileptic discharge as well. Results The latency of seizure in the former group was obviously elongated, the while severity of seizure was obviously alleviated. The time period of epileptic discharge after longer exposure to the magnetic field was significantly shortened, compared with the control and the shorter exposure group. Conclusion Rotational magnetic field of 20 mT can restrain seizure activity in rats. |
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| Keywords: | rotational electromagnetic field epilepsia rat model |
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