藿香正气口服液合用刺五加片缓解海洛因成瘾戒断症状的疗效观察

目的:观察藿香正气口服液(藿香、白芷、苍术、生半夏、陈皮、大腹皮)合用刺五加片对海洛因依赖脱毒后稽延性戒断症状的治疗作用.方法:将143例吸毒者随机分成3组(对照组44例,治疗组A48例,治疗组B51例).三组均采用盐酸洛啡西定(LFX)脱毒治疗12d,脱毒后对照组服模拟制剂,治疗组A脱毒后服用藿香正气口服液和刺五加片60d,治疗组B从服用LFX脱毒开始即服用藿香正气口服液和刺五加片.两治疗组停用藿香正气口服液和刺五加片10d后,分别观察1周内3组相关稽延性戒断症状并评分,1年后尿检调查复吸情况.结果:3组戒断症状评分,治疗组B低于治疗组A(P＜0.01),治疗组A低于对照组(P＜0.01).1年后复吸率治疗组B明显低于对照组(P＜0.05).治疗组B低于治疗组A(P＜0.05).结论:提示藿香正气口服液合用刺五加片能缓解早期戒断症状和中期稽延性戒断症状,有降低1年复吸率的趋势.

Efficacy of Huoxiangzhengqi Oral Liquid and Tablet of Radix et Caulis Acanthopanacis Senticosi on withdrawal symptoms from heroin

AIM:To observe the therapeutic efficacy of Huoxiangzhengqi Oral Liquid (Herba Agastaches seu Pogostemi, Radix Angelicae Dahuricae, Rhizoma Atractylodis, Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Pericarpium Arecae) and Tablet of Radix et Caulis Acanthopanacis Senticosi on the withdrawal symptoms from heroin. METHODS: 143 cases were randomly divided into three groups, namely control group (n=44), treating group A (n=48) and B (n=51). They were detoxified by using Lofexidine Hydrochloride Tablet (LFX) for 12d, and then, the control group took an imitate preparation, the treating group A took Huoxiangzhengqi Oral Liquid and Tablet of Radix et Caulis Acanthopanacis Senticosi for 60d, But group B took Huoxiangzhengqi Oral Liquid and Tablet of Radix et Caulis Acanthopanacis Senticosi from the time when detoxification began. And then, 10d after the two treating groups stopped taking Huoxiangzhengqi Oral Liquid and Tablet of Radix et Caulis Acanthopanacis Senticosi, the protracted abstinent syndromes of the three group were observed and scored for 7d. One year later, the drug re abusing case of the three groups were investigated through urinoscopy. RESULTS: The scores of the protracted abstinent symptoms of the three groups were distinctively different. The scores of the treating group were lower than those of the treating group A ( P <0.01), and the scores of treating group A were lower than those of the control group ( P <0.05). CONCLUSIONS: Huoxiangzhengqi Oral Liquid and Tablet of Radix et Caulis Acanthopanacis Senticosi relieve effectively the withdrawal symptoms in eary time and the protrated abstineat symptoms and reduce the re abuse drugs rate after detoxification.