COX-2、cyclinD1在多形性腺瘤和癌在多形性腺瘤中的表达及意义

目的：研究COX-2、cyclinD1在正常腮腺组织、多形性腺瘤（PA）和癌在多形性腺瘤中（CPA）的表达及相关性,探讨其在肿瘤复发、恶变中的作用.方法：应用免疫组化S-P法检测11例正常腮腺组织,40例PA及12例CPA中的COX-2和cyclinD1表达.结果：COX-2在PA初发瘤、PA复发瘤及CPA中的阳性表达率分别为34.4%、75%、83.3%,显著高于正常腮腺组织的9.09%（P＜0.05）,彼此间有显著性差异（P＜0.05）;cyclinD1在正常腮腺组织、PA初发瘤、PA复发瘤及CPA中的阳性表达率分别为0、37.5%、50%、75%,PA和CPA间阳性表达率有显著性差异（P＜0.05）,PA复发瘤中阳性表达率高于PA初发瘤,但无显著性差异（P＞0.05）;COX-2与cyclinD1在PA和CPA中的表达分别有显著相关性（P＜0.05）.结论：COX-2、cyclinD1在PA、CPA中的过表达与肿瘤的复发、恶变有明显关系,二者在PA、CPA的发生发展中可能具有一定的作用.

Expression and clinical significance of COX-2, cyclinD1 in PA and CPA

Objective:To study the expression and correlation of COX-2,cyclinD1 in normal parotid,pleomorphic adenoma(PA)and carcinoma in pleomorphic adenoma(CPA);and to reveal their roles in the tumor recurrence and malignant transformation of PA and CPA.Method:S-P immunohistochemical staining was used to detect the expression of COX-2 and cyclinD1 in 11 cases of normal parotid tissues,40 cases of PA and 12 cases of CPA.Result:The positive rate of expression of COX-2 in PA and CPA was much higher than that in normal parotid tissues(P<0.05),and the difference among in them was also significant(P<0.05).The positive rate of expression of cyclinD1 in PA and CPA was significantly higher than that in normal parotid tissues(P<0.05),and the difference between in PA and CPA was also significant(P<0.05),but No difference was noted in PA and recurrent PA(P>0.05);In addition,the expression of COX-2 and cyclinD1 in PA was obviously correlated,and the result was the same as that in CPA(P<0.05).Conclusion:The overexpression of COX-2,cyclinD1 in PA and CPA was positively correlated with tumor recurrence and malignant transformation,they probably play an important role in the occurrence and development of CPA in the parotid gland.