| DNA低甲基化与胃癌发病的关系 |
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| 引用本文： | 李爽.DNA低甲基化与胃癌发病的关系[J].国际肿瘤学杂志,2007,34(9):698-701. |
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| 作者姓名： | 李爽 |
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| 作者单位： | 天津医科大学总医院消化内科,300073 |
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| 摘 要： | 随着对胃癌研究的不断深人，人们逐渐开始关注DNA甲基化这种表观遗传学改变在胃癌发病中所起到的作用。DNA甲基化异常有高甲基化和低甲基化之分，两者均与胃癌的发病密切相关。其中DNA低甲基化主要通过影响胃癌原癌基因、肿瘤-睾丸抗原及浸润、转移相关基因的表达，在胃癌的发生发展中发挥重要作用。
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| 关 键 词： | 胃肿瘤 DNA甲基化 表观遗传学 |
| 文章编号： | 1673-422X（2007）09-0698-04 |
| 修稿时间： | 2007-04-10 |
Relationship between DNA hypomethylation and gastric cancer |
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| LI Shuang.Relationship between DNA hypomethylation and gastric cancer[J].Journal of International Oncology,2007,34(9):698-701. |
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| Authors: | LI Shuang |
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| Institution: | Department of Digestion,Tianfin Medical University General Hospital, Tianjin 300073, China |
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| Abstract: | With the development of gastric cancer research, the role of DNA methylation in the generation of stomach neoplasms has been suggested more recently. The abnormal DNA methylation include hypermeth- ylation and hypomethylation. Both of them relate to tumorigenesis of gastric cancer. By affecting the expression of proto-oncogenes, cancer-testis antigens and genes associated with invasion and metastases, DNA hypomethylation plays an important role in the genesis and development of stomach neoplasms. |
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| Keywords: | Stomach neoplasms DNA methylation Epigenesis genetic |
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