COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life |
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Authors: | Henquet C Rosa A Delespaul P Papiol S Fananás L van Os J Myin-Germeys I |
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Institution: | Department of Psychiatry and Neuropsychology, EURON, Maastricht University Medical Centre, South Limburg Mental Health Research and Teaching Network, Maastricht, The Netherlands. cecile.henquet@sp.unimaas.nl |
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Abstract: | Objective: A functional polymorphism in the catechol‐o‐methyltransferase gene (COMT Val158Met) may moderate the psychosis‐inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted. Method: The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (n = 31) and healthy controls (n = 25). Results: Carriers of the COMT Val158Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability. Conclusion: The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val158Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life. |
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Keywords: | Cannabis psychotic disorders Catechol‐o‐methyltransferase gene |
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