血管生成素-2在恶性胸腔积液中的诊断价值

目的探讨血管生成素-2(angiopoietin-2,Ang-2)在良恶性胸腔积液鉴别中的作用。方法选取2007年我院住院的胸腔积液患者90例,其中良性胸腔积液40例,恶性胸腔积液组50例。酶联免疫吸附法(ELISA)检测良性和恶性胸腔积液中Ang-2浓度。结果恶性胸腔积液中Ang-2水平为(71.4±23.5)μg/L,明显高于良性胸腔积液的(31.4±20.6)μg/L,两者比较差异有统计学意义(P<0.05);以46.9μg/L为临界值,Ang-2测定在恶性胸腔积液中灵敏度为90.0%、特异度为82.5%、准确度86.7%。结论胸腔积液中Ang-2测定可作为鉴别良恶性胸腔积液的指标。

The diagnostic value of angiopoietin-2 in malignant pleural effusion

Objective To explore the level of angiopoietin-2(Ang-2) and its significance in benign and malignant pleural effusions.Methods We selected 90 of pleural effusion patents.Of them,40 pleural effusion were diagnosed as benign,and 50 as malignant.The level of Ang-2 pleural effusion in benign pleurisy and malignant pleural effusion were measured by enzyme linked immunosorbent assay(ELISA).Results The level of Ang-2 in malignant pleural effusion(71.4±23.5)μg/L and was significant higher than that in benign effusion(31.4±20.6)μg/L(P<0.01).The cut-off values for Ang-2 was defined at 46.9 μg/L.The sensitivity and specificity and accuracy of Ang-2 for malignant pleural effusion were 90.0% and 82.5% and 86.7%.Conclusion The levels of Ang-2 could be used as valuable parameters for differentiation of benign and malignant effusions.