苏州市结核病乙胺丁醇耐药情况分析

目的了解苏州市地区感染结核分枝杆菌(Mycobacterium tuberculosis,MTB)的结核病患者耐乙胺丁醇情况。方法对2008年9月～2011年5月期间在苏州大学附属传染病医院就诊的肺结核病患者的临床分离株进行菌型鉴定后,用药敏罗氏培养基进行药物敏感性试验,分析结核病患者对一线抗结核药物乙胺丁醇的耐药情况。结果苏州市地区近三年期结核病耐乙胺丁醇总体发生率为10.7%,其在耐多药病例中的发生率为56.1%;2010～2011年度耐乙胺丁醇发生率明显高于2008～2009年度(χ2=5.54,P<0.05),并且其在耐多药中的发生率也呈显著性差异(χ2=4.30,P<0.05)。结论苏州大学附属传染病医院收治的结核病乙胺丁醇耐药总体发生率和在耐多药中的发生率呈上升趋势。

Analysis of Ethambutol resistance of Mycobacterium tuberculosis derived from tuberculosis patients in Suzhou city

Objective To investigate the ethambutol resistance of of Mycobacterium tuberculosis derived from tuberculosis patients diagnosed at the affiliated infectious hospital of soochow university in Suzhou.Methods From September 2008 to May 2011,the type of clinical isolates from the hospital were demonstrated and then the ethambutol resistance of Mycobacterium tuberculosis from the patients was analyzed by drug sensitive test.Results The total ethambutol-resistance rate was 10.7% and the ethambutol-resistance cases occupied a percentage of 56.1% in the multi-drug resistant tuberculosis.The total ethambutol-resistance rate and its percentage occupied in the multi-drug resistant cases arising during 2010~2011 was respectively 12.3% and 61.6%,which was profoundly higher than that occurred in 2008~2009.Conclusion The total ethambutol-resistance rate of Mycobacterium tuberculosis and its rate occurred in the multi-drug resistant cases from the tuberculosis patients in Suzhou city is high and present increasing.