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| CD133+肺癌细胞的干细胞特性研究 | |
| 引用本文： | 王树岗,曾志勇,杨胜生,林建生,袁扬.CD133+肺癌细胞的干细胞特性研究[J].临床肺科杂志,2012,17(5):871-872. |
| 作者姓名： | 王树岗 曾志勇 杨胜生 林建生 袁扬 |
| 作者单位： | 1. 351100,福建,莆田,福建医科大学莆田市第一医院教学医院心胸外科;350025,福建,福州,福建医科大学附属福州总医院心胸外科 2. 福州,福建医科大学附属福州总医院心胸外科,福建,350025 3. 莆田,福建医科大学莆田市第一医院教学医院心胸外科,福建,351100 4. 第二军医大学附属长海医院,上海,200000 |
| 基金项目： | 福建省自然科学基金资助项目 |
| 摘 要： | 目的 收获CD133+肺腺癌细胞并评估其肿瘤干细胞特性.方法 从13例新鲜肺腺癌组织中收获CD133+和CD133-肺腺癌细胞,并进行Transwell侵袭实验、裸鼠成瘤实验等对比研究,观察CD133+和CD133-肺腺癌细胞的差异.结果 13例中有10例发现CD133表达,其阳性表达率最高为13.12%,CD133+和CD133-细胞在侵袭性、致瘤能力上有明显区别.结论 CD133在人肺腺癌组织细胞中广泛表达,CD133+较CD133-人肺腺癌细胞具有更强的侵袭性和致瘤能力. |
| 关 键 词： | CD133 肿瘤干细胞 肺癌 |
Stem cells properties study of CD133+ lung cancer |
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| WANG Shu-gang , ZENG Zhi-yong , YANG Sheng-sheng , LIN Jian-sheng , YUAN Yang.Stem cells properties study of CD133+ lung cancer[J].Journal of Clinical Pulmonary Medicine,2012,17(5):871-872. | |
| Authors: | WANG Shu-gang ZENG Zhi-yong YANG Sheng-sheng LIN Jian-sheng YUAN Yang |
| Institution: | The first Hospital of Putian City,Fujian Medical University Teaching Hospital 351100,China |
| Abstract: | Objective To isolate the CD133+ lung adenocarcinoma cells and evaluate their Stem cells properties.Methods CD133+ and CD133-cells were isolated from 13 fresh lung adenocarcinoma specimens and make comparisons via invasion assay and immunodeficiency mice tumorigenesis assay.Result CD133+ cells were found in 10 of 13 fresh specimens with the highest number is 13.12%.CD133+ and CD133-cells have significant difference in invasiveness and tumorigenesis.Conclusion CD133 is detected in a considerable proportion of lung adenocarcinoma specimens,and the invasive,tumorigenic of CD133+ cells are significant higher than CD133-cells. |
| Keywords: | CD133 Tumor stem cells Lung cancer |
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