莫西沙星对老年耐多药肺结核病的临床观察

目的比较和评价含莫西沙星(MXFX)方案与含左氧氟沙星(LVFX)方案对老年耐多药肺结核病(MDR-PTB)的治疗效果及安全性。方法将80例老年痰菌阳性的MDR-PTB患者随机分成试验组(A组)40例及对照组(B组)40例,A组用含MXFX方案;B组用含LVFX方案,疗程结束时对两组患者进行比较。结果满3个月时痰菌阴转率A组为65%、B组为40%,两组对比差异有统计学意义,满18个月时A组及B组分别为77.5%、72.5%;疗程末影像吸收有效率A组72.5%,B组65%,空洞有效率分别为65%、52.5%;副作用A组30.0%,B组为37.5%。结论 MXFX对老年MDR-PTB的治疗是有效且安全的。

A Clinical Observation of Moxifloxacin's Curative Effects on Senior Patients Troubled by Multi-drug Resistant Pulmonary Tuberculosis

Objective Compare and evaluate the curative effects and security of the MXFX solution and LVFX solution on senior patients troubled by multi-drug resistant pulmonary tuberculosis.Methods Randomly divide 80 MDR-PTB senior patients who are tubercule bacillus positive in sputum into experimental group(group A) of 40 cases and control group(group B) of 40 cases.The group A employs MXFX solution,while group B employs LVFX solution.Compare the two groups at the end of the treatment.Results After three months’treatment,sputum negative conversion rates of group A and group B are 65% and 40% respectively.The difference between the two groups is of statistical significance.After eighteen months’ treatment,the rates are 77.5% and 72.5% respectively.At the end of the treatment,the photographic absorptive effective rates are 72.5% and 65% respectively,and the void effective rates are 65% and 52.5% respectively.The side effect rates of the two groups are 30.0% and 37.5% respectively.Conclusions It is effective and safe to employ MXFX in the treatment of senior patients troubled by multi-drug resistant pulmonary tuberculosis.