氟比洛芬酯用于胸部创伤镇痛的临床观察

目的观察静脉滴注氟比洛芬酯对胸部创伤患者的镇痛效果及安全性。方法 60例以多发肋骨骨折(3根以上)为主的胸部创伤患者随机分为A、B两组,A组给予氟比洛芬酯注射液(凯纷)50 mg加入生理盐水50 ml静脉滴注,B组给予曲马多注射液100 mg肌肉注射。比较起效时间、维持时间及用药前、用药后2、6、24 h疼痛视觉模拟评分(VAS)值,以及副反应观察。结果 A组药物起效时间及持续时间与B组比较差异有统计学意义(P<0.01);两组给药后6 h VAS评分差异有显著性(P<0.01);给药前、给药后2、24 h两组VAS评分比较差异无统计学意义(P>0.05);两组用药后不良反应:A组不良反应率为3.33%,B组不良反应发生率为16.67%。结论氟比洛芬酯用于胸部创伤镇痛效果确切,且副作用少。

Analgesic effect of flurbiprofen axetil for chest trauma

Objective To investigate the analgesic affects and safety of intravenous infusion of flurbiprofen axetil in chest trauma patients.Methods 60 chest trauma patients with multiple rib fractures(three or more) were randomly divided into groups A and B.The flurbiprofen axetil injection(kaifen) 50 mg were given by intravenous infusion in group A.The tramadol injection 100 mg were given by intramuscular injection in group B.VAS scales and the side effects were observed in the two groups during drug onset and duration,before treatment,and 2,6,24 hours after treatment.Result The difference in drug onset time and duration between the two groups was statistically significant(P<0.01);difference between VAS score of the two groups 6 hours after administration was also statistically significant(P<0.01);difference between VAS score of the two groups 2 and 24 hours after administration was not statistically significant(P>0.05).3.33% of group A experienced adverse reactions compared with 16.67% from group B.Conclusion The use of glurbiprofen axetil for chest trauma patients is effective and adverse reactions are less.