非小细胞肺癌中Cyclin D1表达及其临床意义

目的探讨cyclin D1在非小细胞肺癌组织中表达阳性率、与临床病理生理特征的关系及其在预后中的意义。方法标本系胸外科手术切除的石蜡包埋组织,其中NSCLC 56例、肺炎性假瘤12例,以癌旁正常肺组织作内对照。各组年龄,性别没有差别,采用免疫组化定性检测肺组织中cyclin D1的表达。结果(1)NSCLC组免疫组化阳性表达率为62.5%,显著高于癌旁组(30.4%,P=0.001)及肺炎性假瘤组(33.3%,P=0.018)及;(2)与临床病理特征的关系研究中发现,该蛋白高表达在吸烟组、低分化组要高于非吸烟、中高分化组;(3)在随访中发现两组生存时间有差别,免疫组化表达阳性组的生存时间比阴性组的生存时间要短(P=0.048)。结论cyclin D1对NSCLC的诊断、病情的预后均具有一定的临床价值,说明cyclin D1有可能成为肺癌诊断与预后有用的生物标志物。

Expression and clinicopathological significances of cyclin D1 in primary non-small cell lung cancer

Objective To study the relationship between cyclin D1 and non-small cell lung cancer.Methods Specimens were obtained during chest surgery inluding 56 NSCLC,12 pulmonary inflammatory pseudotumor,and 5 normal lungs.All the specimens were matchable in age and sex,cyclin D1 in NSCLC were detected by Immunohistochemical technique.All NSCLC patients ware followed in the study.Results(1)The positive expression rate with anti-cyclin D1 monoclonal antibody in lung cancer tissue was significantly higher than that in ...