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Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics |
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| Authors: | Jose Perea Edurne Alvaro Yolanda Rodr??guez Cristina Gravalos Eva S??nchez-Tom?? Barbara Rivera Francisco Colina Pablo Carbonell Rogelio Gonz??lez-Sarmiento Manuel Hidalgo and Miguel Urioste |
| Institution: | Jose Perea; Edurne Alvaro; Yolanda Rodríguez; Cristina Gravalos; Eva Sánchez-Tomé; Barbara Rivera; Francisco Colina; Pablo Carbonell; Rogelio González-Sarmiento; Manuel Hidalgo; Miguel Urioste Department of Surgery; Hospital Universitario 12 de Octubre; 28041-Madrid; Spain Department of Pathology; Spain Medical Oncology; Spain Human Genetics Group; Human Cancer Genetics Program; Spanish National Cancer Centre; 28029-Madrid; Spa...; |
| Abstract: | AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the study.Clinical information,a three-generation family history,and tumor samples were obtained.MSI status was analyzed and mismatch repair genes were examined in the MSI families.Tumors were included in a tissue microarray and an immunohistochemical study w... |
| Keywords: | Early onset colorectal cancer Microsatellite instability Lynch syndrome Microsatellite stable colorectal cancer |
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