Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas |
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Authors: | Ying-Lung Lin Jui-Kun Chiang Shih-Min Lin and Chih-En Tseng |
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Institution: | Ying-Lung Lin, Jui-Kun Chiang, Department of Family Medicine, Buddhist Tzu-Chi Dalin General Hospital, Chiayi 62247, Taiwan, China;Shih-Min Lin, Department of Biological Sciences, University of Waikato, Hamilton 3216, New Zealand;Chih-En Tseng, Department of Anatomic Pathology, Buddhist Dalin Tzu Chi General Hospital, Chiayi 62247, Taiwan, China; School of Medicine, Buddhist Tzu Chi University, Hualien 97004, Taiwan, China |
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Abstract: | AIM: To investigate the association of colorectal adenomas with both Helicobacter pylori (H. pylori) infection and metabolic syndrome. METHODS: Using a cross-sectional hospital-based study, we analyzed physical examination data from 9311 healthy subjects with overnight physical examinations performed between January 2004 and December 2006. Examined data included gender, age, life style, anthropometric measurements, blood pressure, biochemical and hematological studies, H. pylori infection detected by esophagogastroduodenoscopy and biopsy urease tests, and colorectal adenomas detected with a complete total colonoscopy. RESULTS: The prevalence values for H. pylori infection, metabolic syndrome, and colorectal adenoma were39.2%, 18.7%, and 20.7%, respectively. Colorectal adenoma risk factors included male gender odd ratio (OR): 2.005, 95% conf idence interval (CI): 1.740-2.310, P < 0.001], advanced age (OR: 1.046, 95% CI: 1.040-1.052, P < 0.001), smoking (OR: 1.377, 95% CI: 1.146-1.654, P = 0.001), increased body fat (OR: 1.016, 95% CI: 1.007-1.026, P = 0.001), higher white blood cell count (OR: 1.038, 95% CI: 1.005-1.073, P = 0.025), H. pylori infection (OR: 1.366, 95% CI: 1.230-1.517, P < 0.001), and metabolic syndrome (OR: 1.408, 95% CI: 1.231-1.610, P < 0.001). In addition, concomitant H. pylori infection with metabolic syndrome further increased the probability of colorectal adenomas. CONCLUSION: Our study revealed H. pylori infection with concomitant metabolic syndrome might further increase the risk of colorectal adenomas. |
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Keywords: | Biopsy urease test Colorectal adenoma Colorectal cancer Helicobacter pylori Metabolic syndrome |
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