|
|||||
|
|
| 多型短指软珊瑚Sinularia polydactyla(Ehreberg)中的氧化甾醇 | |
| 引用本文： | 张翠仙,张广文,何细新,林朝展,赵钟祥,祝晨适,苏镜娱,曾陇梅.多型短指软珊瑚Sinularia polydactyla(Ehreberg)中的氧化甾醇[J].中药新药与临床药理,2010,21(1). |
| 作者姓名： | 张翠仙 张广文 何细新 林朝展 赵钟祥 祝晨适 苏镜娱 曾陇梅 |
| 作者单位： | 1. 广州中医药大学中药学院,广州,510006 2. 暨南大学食品科学与工程系,广州,510632 3. 中山大学化学与化学工程学院,广州,510275 |
| 基金项目： | 国家自然科学基金资助，广东省师资队伍建设科研启动经费 |
| 摘 要： | 目的充分利用我国南海药用资源,发现软珊瑚Sinularia polydactyla(Ehreberg)中抗肿瘤和抗炎活性成分。方法采用硅胶柱层析,物理常数比较和波谱方法(NMR、MS等)确定化合物的结构。结果从采自海南三亚海域的多型短指软珊瑚Sinularia polydactyla(Ehreberg)乙醇提取物的乙酸乙酯部位分离得到3个甾体类化合物。通过物理数据比较和波谱方法确定其结构分别是:24-亚甲基-9,11-开环胆甾-5-烯-3β,11-二醇-9-酮(1),9,11-开环麦角甾-5-烯-3β,11-二醇-9-酮(2),麦角甾-3β,5α,6β-三醇(3)。结论化合物1,2,3均首次从此种软珊瑚中得到。体外活性试验表明均具有抗炎活性和显著的细胞毒活性。 |
| 关 键 词： | 软珊瑚 氧化断甾醇 生理活性 |
Analysis of Oxygenated Sterols from the Soft Coral Sinularia polydactyla (Ehreberg) |
|
| ZHANG Cuixian,ZHANG Guangwen,HE Xixin,LIN Chaozhan,ZHAO Zhongxiang ZHU Chenchen,SU Jingyu,ZENG Longmei.Analysis of Oxygenated Sterols from the Soft Coral Sinularia polydactyla (Ehreberg)[J].Traditional Chinese Drug Research & Clinical Pharmacology,2010,21(1). | |
| Authors: | ZHANG Cuixian ZHANG Guangwen HE Xixin LIN Chaozhan ZHAO Zhongxiang ZHU Chenchen SU Jingyu ZENG Longmei |
| Institution: | ZHANG Cuixian1,ZHANG Guangwen2,HE Xixin1,LIN Chaozhan1,ZHAO Zhongxiang ZHU Chenchen1,SU Jingyu3,ZENG Longmei3(1.School of Chinese Herbal Medicine,Guang zhou University of Chinese Medicine,Guangzhou 510006,China,2.Department of Food Science , Technology,Jinan University,Guangzhou 510632,3.School of Chemistry , Chemical Engineering,Sun Yat-Sen University,Guangzhou 510275,China) |
| Abstract: | Objective For utilization of the medicinal sources from South China Sea,antitumour and antiflammaty active constituents of Sinularia polydactyla (Ehreberg) were analyzed. Methods On the basis of to indification of The structures of the active constituents of Sinularia polydactyla (Ehreberg) were identified by silica gel column chromatography,spectroscopic methods (such as NMR and MS) and physical constant comparison. Results Three sterols were first isolated from the ethanol-exacts of soft coral Sinularia p... |
| Keywords: | Sinularia polydactyla Soft coral Sinularia polydactyla Oxygenated sterols Bioactivity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |