内镜鼻窦手术后局部应用Merogel对促进术腔黏膜上皮化的临床效果观察

目的 观察使用美国Xomed公司生产的Merogel(透明质酸)作为内镜鼻窦手术后的术腔填塞物对促进术腔上皮化的作用。方法 对16例(32侧)经鼻内镜全鼻窦开放术患者进行同体对照观察，左侧为Merogel观察组，右侧为空白对照组，连续内镜随访12周，观察双侧术腔上皮化过程。结果 Merogel侧治愈93．75％，好转6．25％，平均上皮化时间3．4周；对照侧治愈87．50％，好转12．50％，平均上皮化时间8．3周。表明使用Merogel侧术腔上皮化时间比对照组明显缩短。结论 内镜鼻窦手术后局部使用Merogel，可以促进术腔上皮化过程。

Clinical evaluation of local application of Merogel after endoscopic sinus surgery]

OBJECTIVE: To study the auxo-action of Merogel (hyaluronic acid) for operative cavity epithelialization after endoscopic sinus surgery (ESS). METHOD: Sixteen patients (32 sides) were observed, in which all sinuses(maxillary, frontal, ethmoid and sphenoid) were operated on by ESS. For the purpose of control study, the left nasal side was used as Merogel group, and right side contrast group. The patients were followed-up for 12 weeks. RESULTS: In Merogel group, the curative rate was 93.75%, improvement rate 6.25%, and average time of epithelialization was 3.4 weeks. In contrast group, the curative rate was 87.50%, improvement rate 12.50%, and average time of epithelialization was 8.3 weeks. It was distinct that in Merogel group, the epithelialization time was shorter than that in contrast group. CONCLUSION: Merogel has auxo-action for operative cavity epithelialization after ESS.