小儿反复呼吸道感染与免疫功能相关关系的研究

目的探讨小儿反复呼吸道感染（RRTI）与免疫功能的关系。方法将RRTI患者归人试验组，将同期就诊的呼吸道感染但非RRTI患儿做对照，即为对照组。首先单因素分析比较两组外周血T淋巴细胞亚群和免疫球蛋白的差异，然后将单因素分析有差异的指标纳入Logistic多元回归模型，进行多因素回归分析，探讨RRTI与免疫功能的关系。结果①试验组IgA、IgM、IgG、CD4＋％和CD47CD8＋水平均低于对照组，差异有统计学意义（P〈0．05）：②多闵素Logistic同归分析显示：IgG每降低l单位，RRTI风险增加18．2％；CD47CD8＋每降低1单位，RRTI风险增加16．1％。结论免疫功能低下是小儿RRTI发生的重要原因。低水平IgG和CD47CD8’是小儿RRTI发生的独立危险因素。

The relationship between immune function and recurrent respiratory tract infection in children

Objective To explore the ralationship between immune function and recurrent respiratory tract infection(RRTI) in children.Methods A total of 156 children were included in the study group,78 of whom suffered RRTI were divided into the observed group,otherwise,were divided into the control group.The difference of the peripheral blood T lymphocyte subsets(CD4+,CD8+ and CD4+/CD8+) and immunoglobulin(IgA,IgM and IgG) were compared using T test.Logistic regression analysis were used to statistic the risk factors of RRTI in children.Results The concentration of IgA,IgM,IgG,CD4+ and CD4+/CD8+ were significantly lower in the observed group than that of the control group.Each point decreased in the concentration of IgG and CD4+/CD8+ increased the risk of RRTI respectly by 18.2%(95%CI=0.384-0.935,P = 0.038)and 16.1%(95%CI=0.223-0.643,P = 0.024)according to Logistic regression analysis.Conclusion Low concentration of IgG and CD4+/CD8+ are the risk factors of RRTI in children.