HBVe系统衍变的临床意义——附465例临床检验结果分析

对３９３例慢性乙肝，７２例乙肝病毒携带者进行乙肝两对半和ＨＢＶ－ＤＮＡ检测，结果为①ＨＢｅＡｇ（＋），ＨＢＶ－ＤＮＡ检出率８５．８％；②ＨＢｅＡｂ（＋），ＨＢＶ－ＤＮＡ检出率２５．９％；③ｅ系统均（－），ＨＢＶ－ＤＮＡ检出率２９．０％。①与②、①与③比较有极显著性差异（Ｐ＜０．０１），②与③比较无显著性差异（Ｐ＞０．０５）。说明ＨＢｅＡｇ和ＨＢＶ－ＤＮＡ密切相关，都是ＨＢＶ复制活跃，具有传染性的指标。部分ＨＢｅＡｇ（－）／ＨＢｅＡｂ（＋）、ＨＢＶ－ＤＮＡ（＋）可能与乙肝病毒基因变异有关

CLINICAL SIGNIFICANCE OF THE SYSTEMETICEVOLUTUON OF HBV

HBV markers and HBV-DNA were tested in 72 cases of hepatitis Type B and 393 cases with chronic hepatitis Type B. The results showed that the HBV-DNA positive rate among HbeAg(+)HBV-DNA was 855%,HbeAb(+)HBV-DNA,25.9% and e system( )HBV-DNA,29%,which proved that there is a significant difference between the former and latter two(P<0.01).It suggests that HbeAg and HBV-DNA are closely related to each other and are both active replication of the HBV virus with infectious indication.Some HbeAg(-)/HbeAb(+),HBV-DNA(+) may have something to do with HBV vari ation.