| Affiliation: | 1.Institute of Epidemiology I,Helmholtz Zentrum München - German Research Center for Environmental Health,Neuherberg,Germany;2.Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine,University Hospital of Munich (LMU),Munich,Germany;3.Institute of Health Economics and Health Care Management,Helmholtz Zentrum München - German Research Center for Environmental Health,Neuherberg,Germany;4.Institute of Epidemiology II,Helmholtz Zentrum München - German Research Center for Environmental Health,Neuherberg,Germany;5.Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research,Munich,Germany |
| Abstract: | PurposeAmong patients with lung disease, decreased lung function is associated with lower health-related quality of life. However, whether this association is detectable within the physiological variability of respiratory function in lung-healthy populations is unknown. We analyzed the association of each EQ-5D-3L dimension (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) and self-reported physical inactivity with spirometric indices in lung-healthy adults. Modulating effects between inactivity and EQ-5D dimensions were considered.Methods1132 non-smoking, apparently lung-healthy participants (48% male, aged 64?±?12 years) from the population-based KORA F4L and Age surveys in Southern Germany were analyzed. Associations of each EQ-5D dimension and inactivity with spirometric indices serving as outcomes (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and mid-expiratory flow) were examined by linear regression, considering possible confounders. Interactions between EQ-5D dimensions (no problems/any problems) and inactivity (four categories of time spent engaging in exercise: inactive to most active) were assessed.ResultsAmong all participants 42% reported no problems in any EQ-5D dimension, 24% were inactive and 32% exercised >?2 h/week. After adjustment, FEV1 was ??99 ml (95% CI ??166; ??32) and FVC was ??109 ml (95% CI ??195; ??24) lower among subjects with mobility problems. Comparable estimates were observed for usual activities. Inactivity was negatively associated with FVC (β-coefficient: ??83 ml, 95% CI ??166; 0), but showed no interactions with EQ-5D.ConclusionsProblems with mobility or usual activities, and inactivity were associated with slightly lower spirometric parameters in lung-healthy adults, suggesting a relationship between perceived physical functioning and volumetric lung function. |
