补骨脂活性成分对骨质疏松相关信号通路影响的研究概况

骨质疏松症(osteoporosis,OP)随社会老龄化进程加速在全球的发病率呈逐渐增长的态势,且致残、致死率较高,临床治疗效果尚不满意。补骨脂作为目前中医药防治OP的研究热点,疗效显著,其活性成分能够干预骨代谢相关信号通路,促进成骨细胞的分化、增殖,抑制破骨细胞的形成,维持骨稳态。本文将从三个方面围绕骨质疏松相关信号通路,对补骨脂活性成分治疗OP的作用机制展开综述,为OP靶向治疗提供依据,为进一步研究和开发抗骨质疏松新药提供前景。

The study of the effect of the active ingredients of fructus psoraleae on the osteoporosis-related signal pathways

Osteoporosis (OP) presents a trend of gradual growth with the accelerated aging process in the society. It represents a high rate of disability and mortality, with dissatisfactory clinical treatment effect. Scurfpea fruit, as a hot spot for prevention and treatment of OP with traditional Chinese medicine, presents a significant remedy. Its active ingredient can interfere with the signal pathways of bone metabolism, promote the differentiation and proliferation of osteoblasts, inhibit the formation of osteoclasts, and maintain the bone homeostasis. This paper summarizes the functional mechanism of active ingredients of scurfpea fruit in the treatment of OP from three aspects on osteoporosis-related signal pathways, provides a basis for targeted treatment of OP, and offers the prospect for further research and development of anti-osteoporosis drugs.