| 清肺通络膏佐治儿童社区获得性肺炎460 例临床疗效观察 |
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| 引用本文： | 张秀英,王雪峰,尚云晓,崔振泽,黄燕,王永生,李迎春,冯彤,苏艳琦,于凤丽,张玲,金学英,孙爱民,刘怡湘,史丹华,张晗,吴振起,赵月. 清肺通络膏佐治儿童社区获得性肺炎460 例临床疗效观察[J]. 世界科学技术-中医药现代化, 2017, 19(12): 2054-2057 |
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| 作者姓名： | 张秀英 王雪峰 尚云晓 崔振泽 黄燕 王永生 李迎春 冯彤 苏艳琦 于凤丽 张玲 金学英 孙爱民 刘怡湘 史丹华 张晗 吴振起 赵月 |
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| 作者单位： | 1. 辽宁中医药大学附属医院 沈阳 110000；,1. 辽宁中医药大学附属医院 沈阳 110000；,2. 中国医科大学附属盛京医院 北京 110032；,3. 大连医科大学附属大连儿童医院 大连 116000；,3. 大连医科大学附属大连儿童医院 大连 116000,4. 鞍山市妇儿医院 鞍山 114000；,5. 锦州市妇儿医院 锦州 121000；,6. 丹东市妇女儿童医院 丹东 118000；,7. 抚顺市矿务局总医院 抚顺 11300；,8. 本溪市中心医院 本溪 117000；,9. 辽河油田中心医院 盘锦 124000；,10. 沈阳市苏家屯区中心医院 沈阳 110032；,11. 新民市妇婴医院 沈阳 110300,5. 锦州市妇儿医院 锦州 121000；,6. 丹东市妇女儿童医院 丹东 118000；,2. 中国医科大学附属盛京医院 北京 110032；,1. 辽宁中医药大学附属医院 沈阳 110000；,1. 辽宁中医药大学附属医院 沈阳 110000； |
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| 基金项目： | 国家科学技术部中医药科研行业专项：儿童社区获得性肺炎中医综合方案推广应用研究（201307007)，负责人：王雪峰；辽宁省中医药临床学（专）科能力建设项目：基于个体化诊疗儿童群体社区获得性肺炎中医综合防治方案推广示范研究（2011-ln?zyxzk-01），负责人：王雪峰；国家自然科学基金面上项目：基于“风温伏肺”理论探讨清肺透邪方对支原体肺炎CARDS毒素损伤的保护机制研究（81774363），负责人：王雪峰。 |
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| 摘 要： | 目的：评价清肺通络膏佐治小儿肺炎的临床疗效及安全性。方法：采用随机对照的临床研究，选取460例肺炎患儿随机分为对照组和观察组，观察组给予清肺通络膏联合基础治疗，对照组单采用基础治疗，对两组患儿疾病的总体疗效，发热、咳嗽、咯痰及气促等单症的消失时间及用药安全性等方面进行评价，并在停药第30天随访呼吸系统疾病发生次数。结果：在疾病疗效方面两组比较，观察组痊愈率98.26%，对照组痊愈率93.89%，痊愈率方面两组比较差异有统计学意义（P<0.05），观察组优于对照组；在咯痰消失时间上比较差异有统计学意义（P<0.05）；在发热、咳嗽和气促的消失时间上比较差异无统计学意义（P>0.05）；停药第30天随访结果两组支气管炎发生次数比较具有统计学意义（P<0.05），上呼吸道感染、肺炎及哮喘的发生次数比较差异无统计学意义（P>0.05）；观察组未见不良反应发生。结论：清肺通络膏联合西药治疗小儿肺炎在疾病疗效、咯痰消失时间及支气管炎的发生次数上明显优于对照组，而且未见明显不良反应，安全有效，预后较好，值得临床推广使用。
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| 关 键 词： | 清肺通络膏 儿童社区 获得性肺炎 临床疗效 安全性 |
| 收稿时间： | 2017-10-19 |
| 修稿时间： | 2017-11-19 |
Clinical Observation on Treatment of 460 Community-acquired Pneumonia Cases in Children with Qing-Fei Tong-Luo Ointment |
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| Zhang Xiuying,Wang Xuefeng,Shang Yunxiao,Cui Zhenze,Huang Yan,Wang Yongsheng,Li Yingchun,Feng Tong,Su Yanqi,Yu Fengli,Zhang Ling,Jin Xueying,Sun Aimin,Liu Yixiang,Shi Danhu,Zhang Han,Wu Zhenqi and Zhao Yue. Clinical Observation on Treatment of 460 Community-acquired Pneumonia Cases in Children with Qing-Fei Tong-Luo Ointment[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2017, 19(12): 2054-2057 |
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| Authors: | Zhang Xiuying Wang Xuefeng Shang Yunxiao Cui Zhenze Huang Yan Wang Yongsheng Li Yingchun Feng Tong Su Yanqi Yu Fengli Zhang Ling Jin Xueying Sun Aimin Liu Yixiang Shi Danhu Zhang Han Wu Zhenqi Zhao Yue |
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| Affiliation: | 1. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China;,1. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China;,2. ShengjingHospital Affiliated of China Medical University, Beijing 110032, China;,3. Dalian Children??s Hospital Affiliated to DalianMedical University, Dalian 116000, China;,3. Dalian Children??s Hospital Affiliated to DalianMedical University, Dalian 116000, China;,4. Anshan Maternal and Children??s Hospital, Anshan 114000, China;,5. Jinzhou Women??s And Children??s Hospital, Jinzhou 121000, China;,6. Dandong Women??s And Children??s Hospital,Dandong 118000, China;,7. General Hospital of Fushun Mining Bureau, Fushun 113000, China;,8. Benxi Central Hospital,Benxi 117000, China;,9. Central Hospital of Liaohe Oil Field, Panjin 124000, China;,10. Central Hospital of ShenyangSujiatun District, Shenyang 110032, China;,11. Xinmin Women??s And Children??s Hospital, Shenyang 110300, China,5. Jinzhou Women??s And Children??s Hospital, Jinzhou 121000, China;,6. Dandong Women??s And Children??s Hospital,Dandong 118000, China;,2. ShengjingHospital Affiliated of China Medical University, Beijing 110032, China;,1. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China; and 1. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China; |
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| Abstract: | This study was aimed to evaluate the clinical effect and safety of Qing- Fei Tong- Luo (QFTL) ointment fortreating children with pneumonia. Randomized controlled trial (RCT) was conducted among 460 cases of children withpneumonia. The observation group was given QFTL ointment combined with basic treatment. And the control group wasonly treated by basic treatment. Evaluation was given on the total clinical efficacy, disappeared time of fever, cough,expectoration, shortness of breath, and medication safety. The incidence of respiratory diseases was followed up on the30th days after drug withdrawal. The results showed that in the aspect of clinical efficacy between two groups, the curerate of the observation group was 98.26%, and that of the control group was 93.89%, with statistic significance (P < 0.05).The cure rate of the observation group was better than that of the control group. There was statistical difference onexpectoration disappeared time (P < 0.05). There was no statistical difference on disappeared time of fever, cough andshortness of breath (P > 0.05). There was statistical difference on the incidence of respiratory diseases on the 30th daysfollowed-up after drug withdrawal (P < 0.05). There was no statistical difference on the incidence of upper respiratorytract infection, pneumonia and asthma (P > 0.05). No adverse reactions occurred in the observation group. It wasconcluded that QFTL ointment combined with basic therapy on the treatment of pneumonia in children was significantlybetter than the control group in the aspect of clinical efficacy, expectoration disappeared time and the incidence ofbronchitis. It is safe and effective. The prognosis is good and worthy of promotion in the clinical practice |
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| Keywords: | Qing-Fei Tong-Luo ointment community-acquired pneumonia in children clinical efficacy safety |
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