| 国内儿童功能性便秘患病率和纤维素治疗有效性的文献评价 |
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| 引用本文： | 杨春松,张伶俐,任燕,许群芬. 国内儿童功能性便秘患病率和纤维素治疗有效性的文献评价[J]. 中国药事, 2017, 31(5): 579-583 |
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| 作者姓名： | 杨春松 张伶俐 任燕 许群芬 |
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| 作者单位： | 四川大学华西第二医院循证药学中心, 成都 610041;四川大学出生缺陷与相关妇儿疾病教育部重点实验室, 成都 610041,四川大学华西第二医院循证药学中心, 成都 610041;四川大学出生缺陷与相关妇儿疾病教育部重点实验室, 成都 610041,四川大学华西第二医院循证药学中心, 成都 610041;四川大学出生缺陷与相关妇儿疾病教育部重点实验室, 成都 610041,四川大学华西第二医院循证药学中心, 成都 610041;四川大学出生缺陷与相关妇儿疾病教育部重点实验室, 成都 610041 |
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| 基金项目： | 国家自然科学基金—中国儿童合理用药评价指标体系的循证研究（编号：81373381） |
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| 摘 要： | 目的：评价国内儿童功能性便秘的患病率和纤维素治疗的疗效。方法：计算机检索PubMed、EMBASE、中国生物医学文献数据库（CBM）、中国期刊全文数据库（CNKI）、中国科技期刊全文数据库（VIP）、万方数据库，全面收集国内儿童功能性便秘患病率和纤维治疗功能性便秘的研究，采用Meta-analyst软件进行Meta分析。结果：共纳入8项患病率研究（84080例患者），Meta分析结果显示，功能性便秘总患病率为6.0%，95% CI（0.025~0.134）。同时纳入9项纤维治疗功能性便秘的研究（750例患者），结果显示，小麦纤维添加治疗能有效治疗功能性便秘[RR=1.49，95%CI（1.13，1.96）, I2=97%]。结论：国内儿童功能性便秘的患病率较高，小麦纤维素是治疗功能性便秘的有效药物，但由于受到纳入研究数量和质量的限制，有待进一步研究证实。
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| 关 键 词： | 功能性便秘 患病率 纤维素 儿童 Meta分析 |
| 收稿时间： | 2016-10-15 |
Meta-analysis of Prevalence and Cellulose Therapy for Functional Constipation of Children in China |
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| Yang Chunsong,Zhang Lingli,Ren Yan and Xu Qunfen. Meta-analysis of Prevalence and Cellulose Therapy for Functional Constipation of Children in China[J]. Chinese Pharmaceutical Affairs, 2017, 31(5): 579-583 |
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| Authors: | Yang Chunsong Zhang Lingli Ren Yan Xu Qunfen |
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| Affiliation: | Evidence-based Pharmacy Center, West China Second Hospital, Sichuan University, Chengdu 610041, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China,Evidence-based Pharmacy Center, West China Second Hospital, Sichuan University, Chengdu 610041, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China,Evidence-based Pharmacy Center, West China Second Hospital, Sichuan University, Chengdu 610041, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China and Evidence-based Pharmacy Center, West China Second Hospital, Sichuan University, Chengdu 610041, China;Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China |
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| Abstract: | Objective: To analyze the prevalence and the efficacy of cellulose therapy for functional constipation (FC) of children in China. Methods: We surfed on PubMed, EMBASE, CBM, CNKI, VIP and Wanfang databases, comprehensively collected the studies on the prevalence of FC and the efficacy of cellulose therapy for FC of children, and carried out Meta-analysis using Meta-analyst software. Results: Meta-analysis showed that the total prevalence of FC in mainland China was 6.0%, accounting for 95% CI (0.025-0.134) among the 8 included studies (84080 patients). Meta-analysis also showed that there was significant difference for the efficacy rate between wheat cellulose groups and open control group during the treatment period[RR=1.49, 95%CI (1.13, 1.96) I2=97%] among 9 included studies (750 patients) of evaluating the efficacy of fiber therapy for FC. Conclusion: The prevalence of FC of children in China is relatively high. The wheat cellulose is an effective drug for the treatment of FC. The results need to be confirmed by additional studies due to the limitations of the quantity and quality of the study. |
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| Keywords: | functional constipation prevalence cellulose children Meta-analysis |
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