艾灸治疗膝骨关节炎的系统性评价及Meta分析

目的探讨艾灸对膝骨关节炎的干预效果。方法通过检索Pubmed、Embase、Cochrane Central Register of Controlled Trials、CINAHL、中国期刊全文数据库(CNKI)和万方数据库,收集艾灸治疗膝骨关节炎的随机对照试验,对相关文献进行质量评价和数据提取,并以疼痛数字量表评分(numerical rating scale,NRS)、SF-36生活质量评分、WOMAC骨性关节炎总评分为结局指标进行Meta分析。结果最终纳入7篇文献,文献证据质量中等。Meta分析结果显示,与对照组相比,艾灸干预可以有效改善膝骨关节炎患者的疼痛和生活质量,差异有统计学意义(P0.05);组间临床症状和体征(WOMAC评分)差异虽无统计学意义(P0.05),但艾灸干预组有进一步改善的趋势。结论艾灸干预可以让膝骨关节炎患者获益;后续研究需重视相应的方法学质量及客观结局指标。

Moxibustion in the treatment of keen osteoarthritis:A systematic review and Meta analysis

  Objective:To discuss the intervention effects of moxibustion on knee osteoarthritis. MethodsBy searching resource from data base such as Pubmed,Embase,Cochrane Central Register of Controlled Trials,CINAHL,China national knowledge infrastructure(CNKI),Wangfang and so on,the randomized controlled trials(RCTs)about moxibustion in the treatment of knee osteoarthritis were collected. The quality evaluation and data extraction were performed on the relevant literatures,and the Meta analysis was conducted based on outcome indexes including pain numerical rating scale(NRS)score,SF-36 scale score of quality of life and total score of Western Ontario and McMaster Universities osteoarthritis index(WOMAC).  Results:Finally 7 literatures were included,and the quality of the documents was in the medium level. The results of Meta analysis showed that compared with the control group,moxibustion intervention could effectively improve the pain and life quality of patients with knee osteoarthritis,with statistical differences(P<0.05).There was no statistical difference on WOMAC score(clinical symptoms and signs)between the two groups(P>0.05),but the improvement trend was observed in the moxibustion intervention group.  Conclusion:Moxibustion intervention can benefit the patients with knee osteoarthritis. Subsequent research should pay attention to the corresponding methodological quality and objective outcome indicators.