| 熊胆及其潜在替代资源研究概况 |
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| 引用本文： | 张学延,王天明,吴家胜,马越鸣.熊胆及其潜在替代资源研究概况[J].上海中医药杂志,2017,51(9):114-117. |
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| 作者姓名： | 张学延 王天明 吴家胜 马越鸣 |
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| 作者单位： | 上海中医药大学中药学院,上海,201203,上海中医药大学中药学院,上海,201203,上海中医药大学中药学院,上海,201203,上海中医药大学中药学院,上海,201203 |
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| 基金项目： | 国家“十二五”重大新药创制专项(ZX093013606-007) |
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| 摘 要： | 对比分析天然熊胆与熊胆的人工制品以及其他动物胆汁在化学成分、药理作用、临床应用等方面的异同。研究发现,人工合成熊胆在结合型胆汁酸牛磺熊去氧胆酸(TUDCA)、牛磺鹅去氧胆酸(TCDCA)的含量以及利胆、镇静、抗菌等药理作用方面在一定程度上已经达到天然熊胆的水平,可为寻找天然熊胆的替代资源提供参考。
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| 关 键 词： | 熊胆 胆汁酸 化学成分 药理作用 临床应用 替代 |
| 收稿时间： | 2017/4/12 0:00:00 |
Review on bear bile and its potential alternative resources |
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| ZHANG Xue-yan,WANG Tian-ming,WU Jia-sheng and MA Yue-ming.Review on bear bile and its potential alternative resources[J].Shanghai Journal of Traditional Chinese Medicine,2017,51(9):114-117. |
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| Authors: | ZHANG Xue-yan WANG Tian-ming WU Jia-sheng and MA Yue-ming |
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| Institution: | School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai,201203,School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai,201203 and School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai,201203 |
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| Abstract: | This article analyzed and compared the similarities and differences on chemical components,pharmacological effects and clinical application between natural bear bile and its artificial products or other animal bile. Research found that the contents of conjugated bile acids including tauroursodesoxycholic acid(TUDCA)and taurochenodeoxycholic acid(TCDCA)in artificially synthesized bear bile and its cholagogic,sedative and antibacterial effects were approximate to those of natural bear bile to some extent,which provided reference for searching alternative resources of natural bear bile. |
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