| 清肠温中方对溃疡性结肠炎大鼠干扰素γ诱导蛋白10 的影响 |
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| 引用本文： | 毛堂友,史瑞,谢添弘,郭一,陈晨,石磊,贾博宜,刘佳丽,谭祥,韩亚飞,丁庞华,李军祥.清肠温中方对溃疡性结肠炎大鼠干扰素γ诱导蛋白10 的影响[J].世界科学技术-中医药现代化,2017,19(11):1836-1840. |
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| 作者姓名： | 毛堂友 史瑞 谢添弘 郭一 陈晨 石磊 贾博宜 刘佳丽 谭祥 韩亚飞 丁庞华 李军祥 |
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| 作者单位： | 北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078,北京中医药大学东方医院脾胃肝胆科 北京 100078 |
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| 基金项目： | 国家自然科学基金委青年基金项目：清肠温中方对溃疡性结肠炎大鼠MSP-RON通路的调控机制研究（81403369），负责人：史瑞；北京市科技计划项目：十病十药研发——清肠温中方治疗溃疡性结肠炎的中药制剂的开发研究(Z151100003815011)，负责人：李军祥。 |
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| 摘 要： | 目的：研究清肠温中方对溃疡性结肠炎大鼠结肠组织干扰素γ诱导蛋白10（IP10）的影响。方法：自由饮用4.5% DSS溶液7天制备UC模型，同时给予清肠温中方低剂量、中剂量、高剂量及美沙拉嗪（莎尔福）进行灌胃干预，处死大鼠，取结肠组织，应用酶联免疫吸附法检测结肠白介素-1α（IL-1α）、IL-1β、IL-6、肿瘤坏死因子-α（TNF-α）、γ-干扰素（INF-γ）的表达水平，免疫组织化学法检测IP10的蛋白表达及分布。结果：与正常组相比，DSS诱导的UC大鼠结肠炎症因子（IL-1α、IL-1β、IL-6、TNF-α、INF-γ）和IP10的表达水平均显著升高，而经过7天的干预后，结肠炎症因子（IL-1α、IL-1β、IL-6、TNF-α、INF-γ）和IP10的表达水平明显降低（p<0.01，p<0.05）。结论：清肠温中方能够通过抑制IP10的表达，下调结肠炎症因子（IL-1α、IL-1β、IL-6、TNF-α、INF-γ）的水平，从而抑制肠道抑制炎症、修复肠粘膜损伤，达到治疗溃疡性结肠炎的目的。
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| 关 键 词： | 清肠温中方 溃疡性结肠炎 干扰素γ 诱导蛋白10 调控作用 |
| 收稿时间： | 2017/10/6 0:00:00 |
| 修稿时间： | 2017/10/28 0:00:00 |
Study on Effect of Qing-Chang Wen-Zhong Decoction on Interferon GammaInduced Protein 10 in Ulcerative Colitis Rats |
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| Mao Tangyou,Shi Rui,Xie Tianhong,Guo Yi,Chen Chen,Shi Lei,Jia Boyi,Liu Jiali,Tan Xiang,Han Yafei,Ding Panghua and Li Junxiang.Study on Effect of Qing-Chang Wen-Zhong Decoction on Interferon GammaInduced Protein 10 in Ulcerative Colitis Rats[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2017,19(11):1836-1840. |
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| Authors: | Mao Tangyou Shi Rui Xie Tianhong Guo Yi Chen Chen Shi Lei Jia Boyi Liu Jiali Tan Xiang Han Yafei Ding Panghua and Li Junxiang |
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| Institution: | Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China,Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China and Spleen, Stomach And Hepatobiliary Department, Dongfang Hospital Affiliated toBeijing University of Chinese Medicine, Beijing 100078, China |
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| Abstract: | |
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| Keywords: | Qing-Chang Wen-Zhong decoction ulcerative colitis interferon gamma inducible protein 10 regulationeffect |
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