基因多态性与支气管哮喘

支气管哮喘(bronchial asthma),是一种由多种免疫细胞和细胞因子参与的慢性肺部疾病,以可逆性气道阻塞、气道高反应性和气道炎症为特征,并且具有一定的遗传倾向性。研究显示基因多态性在哮喘发病过程中起重要作用,对哮喘基因多态性的研究有助于对分子病理生理学的了解和治疗靶位的探讨,本文就几种哮喘易感性基因的多态性做一综述。

Gene polymorphism and bronchial asthma

Bronchial asthema is a chronic pulmonary disease participated by many sorts of immunocytes and cytokines, characterized by reversibility airway obstruction, airway hyperreactivity and airway inflammation, additionally, it has certain genetic predisposition. Recent studies suggest that gene polymorphism plays a significance role in the cause of bronchial asthma. The research of gene polymorphism in bronchial asthma is useful to understand the molecular pathophysiology of bronchial asthema and explore the therapeutic targets. This article reviews several susceptibility gene of asthma.