难治性肺炎支原体肺炎患儿院内感染危险因素分析

目的：探讨难治性肺炎支原体肺炎（RMPP）患儿发生院内感染的危险因素，指导临床预防与控制院内感染。方法：回顾性分析我院2012年3月至2014年3月收治的132例RMPP患儿的临床资料，以其中发生院内感染的13例为观察组，未发生院内感染的119例为对照组，对院内感染相关因素进行分析（先行单因素分析，再对有统计学意义的因素进行多因素非条件Logistic回归分析）。结果：132例RMPP患儿中发生院内感染13例（9.85%）。单因素分析显示，RMPP患儿发生院内感染与年龄、住院时间、特殊体质、侵入性操作、季节、C-反应蛋白（CRP）水平及补体C3水平相关（P<0.05）；多因素Logistic回归分析显示，年龄<2岁、住院时间≥20 d、侵入性操作、高CRP水平、低补体C3水平是RMPP患儿发生院内感染的独立危险因素（P<0.05）。结论：RMPP患儿有发生医院内感染风险，医院需加强院内感染监控力度，针对其危险因素及时采取有效的防控措施，以降低院内感染发生率。

Risk Factors Analysis on Hospital Infection Occurrence of Children Refractory Mycoplasma Pneumonia

Objective: It discussed the risk factors on hospital infection of children refractory mycoplasma pneumonia (RMPP) to guide the clinical prevention and control the occurrence of hospital infection. Methods: The retrospective analysis of clinical data was conducted in 132 children with refractory MPP treated in our hospital from March 2012 to March 2014, 13 children with hospital infection were in the case group, and 119 children without hospital infection were in the control group. The comparison was made between two groups with in clinical data, and single factor analysis of related factors was carried out first, then multi-factor unconditioned logistic regression analysis with statistical significance was carried. Results: For the 132 cases with RMPP, there were 13 children were infected within two years, and the infection rate was 9.85%. Single factor analysis showed that age, length of hospital stay, special physical fitness, invasive operation, season, C-reactive protein (CRP) level and C3 level were related to hospital infection (P<0.05), and multi-factor logic regression analysis showed that age less than 24 months, length of hospital stay more than 20 days, invasive operation, high CRP level, low C3 level were the single risk factor of hospital infection (P<0.05). Conclusion: Pediatric patients have the potential occurrence of nosocomial infection, hospital infection monitoring needed to be strengthened, and timely and effective prevention and control measures should be taken on hospital infection factors to reduce the infection rate.