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| 青海藏族人群ADH3、ALDH2基因多态性及其与饮酒行为的关系 | |
| 作者姓名： | Liu Y Li X Wang C Zhang B |
| 作者单位： | 1. 兰州大学公共卫生学院卫生毒理所,兰州,730000 2. 甘肃省肃南县医院 3. 青海省疾病预防控制中心传染所 |
| 摘 要： | 目的 了解青海藏族男性乙醇脱氢酶3(ADH3)和乙醛脱氢酶2(ALDH2)基因多态性分布及其与饮酒行为的关系.方法 采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法对ADH3和ALDH2基因型进行检测;采用回顾性问卷调查研究对象的饮酒行为.结果 等位基因ADH3*2和ALDH2*2在藏族人群中的比例分别为7.79％和22.21％;不饮酒组中等位基因ALDH2*2、ADH3*1频率高于饮酒者;危险饮酒组中等位基因ALDH2*2、ADH3*1频率低于安全饮酒者.结论 ADH3、ALDH2基因与青海藏族男性人群饮酒行为有关. |
| 关 键 词： | 乙醇脱氢酶3 乙醛脱氢酶2 藏族 |
Genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior |
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| Liu Y,Li X,Wang C,Zhang B.Genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior[J].Journal of Hygiene Research,2011,40(6):784-786. | |
| Authors: | Liu Yan Li Xingxiang Wang Chaocai Zhang Benzhong |
| Institution: | LIU Yan,LI Xingxiang,WANG Chaocai,ZHANG Benzhong Department of Toxicology,College of Public Health,Lanzhou University,Lanzhou 730000,China |
| Abstract: | Objective To investigate the genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was used to detect the genotype of ADH3 and ALDH2.Drinking behavior was obtained by questionnaire.Results The frequency of ADH3 * 2 and ALDH2 * 2 alleles in Tibetan population was 7.79% and 22.21% respectively,the frequency of ALDH2 * 2 and ADH3 * 1 alleles in non-drin... |
| Keywords: | alcohol dehydrogenase 3 aldehyde dehydrogenase 2 tibetan |
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