| FOLFOX4和XELOX一线方案治疗晚期结直肠癌的疗效分析 |
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| 引用本文： | 盛莉莉,朱益平,吉兆宁.FOLFOX4和XELOX一线方案治疗晚期结直肠癌的疗效分析[J].皖南医学院学报,2011,30(6):464-467. |
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| 作者姓名： | 盛莉莉 朱益平 吉兆宁 |
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| 作者单位： | 皖南医学院附属弋矶山医院肿瘤内科,安徽芜湖24100l |
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| 摘 要： | 目的：比较FOLFOX4与XELOX方案治疗晚期结直肠癌的近期疗效及安全性。方法：收集62例晚期初治结直肠癌患者,采用FOLFOX4方案治疗32例,采用XELOX方案治疗30例。结果：FOLFOX4组有效率50%,XELOX组有效率46.7%,两组中位疾病进展时间（MTTP）分别为6.5个月和6.0个月,P〉0.05,两组无统计学意义。XELOX组Ⅲ～Ⅳ级中性粒细胞减少率和神经毒性发生率分别为3.3%和6.7%,明显低于FOIFOX4组的9.4%和18.8%（P〈0.05）;XELOX组手足综合征发生率为13.3%,高于FOL-FOX4组的3.1%（P〈0.05）,但程度较轻,主要为Ⅰ～Ⅱ度。结论：XELOX方案与FOLFOX4方案的疗效相近,毒副反应均可耐受,但XELOX方案组患者依从性较好。
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| 关 键 词： | 结直肠癌 FOLFOX4方案 XELOX方案 |
Therapeutic outcomes of FOLFOX4 regimen versus XELOX regimen for advanced colorectal cancer |
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| SHENG Li-li,ZHU Yi-ping,JI Zhao-ning.Therapeutic outcomes of FOLFOX4 regimen versus XELOX regimen for advanced colorectal cancer[J].Acta Academiae Medicinae Wannan,2011,30(6):464-467. |
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| Authors: | SHENG Li-li ZHU Yi-ping JI Zhao-ning |
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| Institution: | SHENG Li-li,ZHU Yi-ping,JI Zhao-ning Department of Oncology,Yijishan Hospital,Wanan Medical College,Wuhu 241001,Chin |
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| Abstract: | Objective:To compare the short-term therapeutic effect and adverse reactions between oxaliplatin plus fluorouracil and calcium folinate(FOLFOX4 regimen) and combined oxaliplatin with capecitabine(XELOX regimen) in treatment of advanced colorectal cancer.Methods:Sixty-two patients with advanced gastric cancer were allocated two groups.One group(n=32) received FOLFOX4 regimen as first-line chemotherapy and another(n=30) were given XELOX regimen.Results:The overall response rate(CR+PR) was 50%(FOLFOX4) vs 46.7... |
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| Keywords: | colorectal cancer FOLFOX4 regimen XELOX regimen |
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