采用未成熟网织红细胞指数监测恶性肿瘤患者放疗前、后骨髓功能恢复的临床价值

目的　探讨采用未成熟网织红细胞指数 (IRF)监测恶性肿瘤患者放疗前、后骨髓功能恢复的临床价值。方法　采用XE 2 10 0型血液细胞分析仪检测未成熟网织红细胞指数 (IRF)、网织红细胞比率 (RET)和嗜中性粒细胞计数 (NEUT )。结果　患者组放疗后第 10天以上 3项指标均显著低于对照组 (P <0 .0 1) ,放疗后第 15天IRF开始增高 ,并显著高于第 10天的水平 (P <0 .0 1) ,而RET、NEUT未发生显著改变 (P >0 .0 5 ) ,患者组放疗后第 2 0天IRF继续升高 ,并显著高于第 15天的水平 (P <0 .0 1) ,RET和NEUT也开始增高 ,但与第 15天比较 ,无显著性差异 (P >0 .0 5 )。患者组放疗后第 2 5天 ,IRF已经基本恢复至放疗前水平 ,RET和NEUT也开始显著升高 ,但仍低于放疗前水平 (P <0 .0 1)。结论　肿瘤患者IRF升高较RET和NEUT要早。未成熟网织红细胞指数是放、化疗时反映骨髓抑制和恢复较敏感的指标

The clinical value of immature reticulocyte fraction in monitoring the recovery of bone marrow function after radiotherapy

Objective To investigate the clinical value of immature reticulocyte fraction(IRF)in evaluating the recovery of bone marrow function after radiotherapy.Methods IRF,the ratio of reticulocytes(RET)and counting of neutrophilic granulocytes(NEUT)were detected by Sysmex XE-2100 automated reticulocyte analyzer.Results On the 10th day of radiotherapy,the three indexes in the treatment group are much lower than those in control group.On the 15th day,the IRF in the treatment group began to increase and became higher than that on the 10th day(P<0.01),but there were no difference between RET and NEUT(P>0.05).On the 20th day,IRF continued increasing and become higher than that in the 15th day(P<0.01);RET and NEUT also began to increase and they were not markedly different from the values on 15th day,respectively(P>0.05).On the 25th day,IRF nearly recovered to the level of pre-radiotherapy.RET and NEUT began to increase significantly,which were still lower than that of pre-radiotherapy(P<0.01).The increase of IRF is earlier than that of RET and NEUT.Conclusion The immature reticulocyte fraction(IRF)is an early indicator for evaluating hematopoietic recovery of the bone marrow after radiotherapy or chemotherapy.