咪达唑仑对剖宫产术初产妇情绪和记忆的影响

目的 探讨咪达唑仑对剖宫产手术产妇情绪和记忆的影响.方法 72例择期剖宫产术产妇随机分成4组,Ⅰ、Ⅱ和Ⅲ组麻醉前30 min分别肌注咪达唑仑0.05、0.06和0.07 mg/kg,Ⅳ组肌注生理盐水1.5 ml,同时肌肉注射阿托品0.01 mg/kg.于注药前和注药后30 min进行焦虑视觉类比试验(AVAT)、状态焦虑问卷(SAI)测试及Ramsay镇静水平评估.将麻醉准备到手术结束过程分为5阶段,每项告知产妇,记录剖宫产术后4 h产妇能准确回忆的项目.结果 注药后30 min时,Ⅰ～Ⅲ组AVAT分别下降36.4%、43.2%和43.1%;SAI分别下降20.9%、24.8%和26.9%,均获得Ramsay 2～4级镇静水平.Ⅰ～Ⅲ组和Ⅳ组比较记忆保留组间差异均有统计学意义(P均＜0.01).Ⅰ～Ⅲ组以遗忘静脉穿刺过程的居多,4组产妇对椎管内麻醉穿刺和新生儿娩出后性别识别两过程全部记忆完觋整.结论 剖宫产手术前给予咪达唑仑0.05～0.07 mg/kg,对产妇有良好的镇静和抗焦虑作用,对外显记忆有一定程度的影响,其中对信息量小和关注程度低的信息能产生顺行性遗忘作用,能保留信息量大和关注程度高的信息的完整记忆.

Emotion and memory effects of midazolam on primipara undergoing caesarean section

Objective To investigate the emotion and memory effects of midazolam as a premedication on primipara undergoing caesarean section. Methods Seventy-two primiparous women scheduled for elective caesarean section were randomly divided into four groups. In group Ⅰ,Ⅱand Ⅲ,intramuscular midazolam 0.05 mg/kg,0.06 mg/kg and 0.07 mg/kg were given respectively. The primiparae in group Ⅳ were given intramuscular normal saline 1.5 ml. Anxiety vision analogy test(AVAT) , state anxiety index testing(SAIT) and Ramsay score were evaluated before and 30 min after injection of above drugs. The primiparae were informed when several stages of anesthesia and surgery began. Four hours after the caesarean section they would recall those stages. Accurate remembrance was recorded. Results Thirty minutes after injection,AVAT declined by 36.4% ,43.2% ,43.1% in group Ⅰ,Ⅱand Ⅲ respectively,while SAI decreased by 20.9% ,24.8% ,26.9% respectively. Ramsay 2～4 levels were attained in all the primiparae. There was significant difference between treatment groups and control group in scores of memory (P＜0.01). Most primiparae in treatment groups forgot the process of venipuneture, but all maternals could recall the process of anesthesia and identify the gender of neonates. Conclusions Good sedation and anxiolysis can be obtained when midazolam 0.05～0.07mg/kg as premedicaton is used for caesarean section,which affect effects on the explicit memory in part, and produces anterograde amnesia effect on the small amount and little-attention information, while keeps panmnesia of the large amount and close-attention information.