Development and use of a gastropathy index for ranking the safety of non-steroidal anti-inflammatory drugs in the elderly |
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| Authors: | V. F. Trewin PhD,MRPharmS,C. J. Lawrence BSc,CStat',&dagger ,S. A. Rae MB,BS,MRCP, G. B. A. Veitch PhD,FRPharmS,FRSC,&Dagger |
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| Affiliation: | *Royal Devon &Exeter Hospital Barrack Road, Exeter EX2 5DW;†Department MSOR, University of Exeter, Laver Building, North Park Road, Exeter EX4 4QE;‡Welsh Office, Cathays Park, Cardiff CF1 3NQ, U.K. |
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| Abstract: | This study, conducted at the Royal Devon & Exeter Hospital, Department of Geriatric Medicine, was carried out using 2987 sets of admission data. The number of patients taking non-steroidal anti-inflammatory drugs was identified together with a suite of clinical factors used to indicate the presence of gastrointestinal pathology. From this a gastropathy index was developed to establish a rank order for the individual drugs. Ketoprofen, piroxicam and fenbufen were all significantly associated with factors suggestive of gastropathy, whereas indomethacin, diclofenac and ibuprofen appeared relatively free of such association. Naproxen, azapropazone and mefenamic acid ranked in an intermediate category. This noninvasive analysis of routinely acquired data provides a potentially useful discriminator between individual non-steroidal anti-inflammatory drugs for this age group. |
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