| 160名成人接种重组酵母乙肝疫苗效果观察 |
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| 引用本文： | 陈维力,卢若翩,徐梅娇,赖浪平. 160名成人接种重组酵母乙肝疫苗效果观察[J]. 中国热带医学, 2008, 8(8): 1412-1413 |
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| 作者姓名： | 陈维力 卢若翩 徐梅娇 赖浪平 |
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| 作者单位： | 1. 深圳市龙岗区大鹏预防保健所,广东,深圳,518120
2. 深圳市龙岗区卫生监督所,广东,深圳,518172 |
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| 摘 要： | 目的探讨成人接种重组酵母乙型肝炎疫苗（YDV）的免疫效果。方法选择160名23-48岁身体健康状况良好的中学老师，其乙型肝炎表面抗原（HBsAg）、乙型肝炎表面抗体（抗-HBs）、乙型肝炎核心抗体（抗-HBc）3项指标均为阴性。按0、1、6个月程序，每剂10μg/1.0ml接种YDV。结果第1针免疫注射后的第12、24个月时，抗-HBs阳转率分别为83、75％、67、50％。女性抗-HBs阳转率均高于男性（P〈0．05）。小于35岁组的抗-HBs阳转率均高于35岁以上组（P〈0．05）。接种重组酵母乙型肝炎疫苗后，本组观察对象均无局部和全身不良反应。结论重组酵母乙型肝炎疫苗对成人具有良好的免疫原性和安全性。
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| 关 键 词： | 重组酵母乙型肝炎疫苗 成人 免疫效果 |
Observation on the results of vacination of recombinant yeast hepatitis B vaccine in 160 adults |
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| Affiliation: | CHEN Wei-li, LU Ruo -pian, XU Mei -jiao, et al. (Longgang District Dapeng Health Care Center, Shenzhen 518120, Guangdong, P. R. China) |
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| Abstract: | Objective To survey the protective effect of recombinant yeast - derived hepatitis B vaccine （YDV） on adults. Methods The immuological indexes in 160 healthy middle school teachers aged 22-48 years after vaccination with YDV were surveyed. Results The positive rates of anti - HBs were 83.75% ,67.50% at the 12th and 24th months respec-tively, higher in women than that in men （P 〈 0.05 ）. The positive rates of anti-HBs in age group under 35 year was higher than that above 35 years-old group （P 〈 0.05）. Conclusion YDV is effective and safety to adults. |
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| Keywords: | Recombinant yeast -derived hepatitis B vaccine Adult Immune result |
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