复方地塞米松预防气管插管术后气道并发症的临床研究

目的:探讨复方地塞米松软膏对全麻插管术后气道并发症的预防作用。方法:90例术前无任何呼吸道症状、无抽烟嗜好,ASA分级1～2级,拟在气管插管全麻下行单侧乳突根治术成人患者,随机分为3组,A组(复方地塞米松组,n=30)、B组(复方利多卡因乳膏组,n=30)和C组(石蜡油组,n=30),在插管前气管导管前端1/3分别均匀涂抹地塞米松软膏2 g、利多卡因软膏2 g和石蜡油,手术结束病人快速苏醒,术后随访评估气道并发症发生率和严重程度。结果:A组、B组与C组相比,术后气道症状的发生率明显降低(P<0.01),A组与B组相比,咳嗽的发生率较低(P<0.05),且C组的严重咳嗽、咳痰发生率高于A组和B组(P<0.01)。结论:复方地塞米松软膏能有效预防和降低术后气道并发症。

The clinical research of compound dexamethasone gel applied over tracheal tube to prevent postoperative airway complications

Objective: To evaluate the effect of compound dexamethasone gel on the incidence and severity of airway symptoms induced by orotracheal intubation. Methods: Ninty adult patients without respiratory symptoms and smoking habits preoperatively were adopted.The patients had ASA classⅠ-Ⅱ levels and were treated with uni-lateral tympanoplasty under general anesthesia requiring orotracheal intubation.Patients were expected to quickly awake after the surgery.The patients were randomly divided into three groups including groupA,group B and the group C which were treated with compound dexamethasone gel,lidocaine gel and liquid paraffin respectively.The incidence and severity of postoperative respiratory symptoms were evaluated. Results: The incidence and severity of postoperative airway complications are lower in group A group B compared with group C(P<0.05);The incidence of cough in group A is lower than that of group B(P<0.05);the serious coughing and Much sputum cases of group C are more than group A and group B(P<0.01). Conclusion: Compound dexamethasone gel could effectively reduce the incidence of postoperative airway complications,and it can be promoted in the clinical practice.