| 变应性鼻炎患者血清IL-2、IL-4及IL-12含量及意义 |
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| 引用本文： | 魏燕高,肖喜艳,巴云鹏. 变应性鼻炎患者血清IL-2、IL-4及IL-12含量及意义[J]. 河南医学研究, 2012, 21(1): 88-89,92 |
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| 作者姓名： | 魏燕高 肖喜艳 巴云鹏 |
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| 作者单位： | 郑州大学第一附属医院鼻科 河南郑州450052 |
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| 摘 要： | 目的:探讨变应性鼻炎患者外周血清中白细胞介素-2(IL-2)、白细胞介素-4(IL-4)及白细胞介素-12(IL-12)的表达及3者在变应性鼻炎发生、发展过程中的作用。方法:酶联免疫吸附试验(Enzyme linked im-munosorbent assay,ELISA)检测实验组(20例)及对照组(20例)外周血清中IL-2、IL-4及IL-12的含量,并进行统计分析。结果:试验组外周血清中IL-2、IL-12检测值明显比对照组低,差异有统计学意义(P<0.05);而IL-4则比对照组高,有统计学意义(P<0.05)。结论:血清中IL-2、IL-12、IL-4可能在变应性鼻炎的发病机理及治疗方面有一定的意义。
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| 关 键 词： | 白细胞介素-2 白细胞介素-4 白细胞介素-12 变应性鼻炎 |
Expression levels and significance of IL-2, IL-4 and IL -12 in serum of patients with allergic rhinitis |
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| WEI Yan-gao , XIAO Xi-yan , BA Yun-peng. Expression levels and significance of IL-2, IL-4 and IL -12 in serum of patients with allergic rhinitis[J]. Henan Medical Research, 2012, 21(1): 88-89,92 |
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| Authors: | WEI Yan-gao XIAO Xi-yan BA Yun-peng |
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| Affiliation: | (Department of Rhinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China) |
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| Abstract: | Objective: To detect the expression level and role of interleukin-2,interleukin-4,interleukin-12 in the peripheric serum in the allergic rhinitis. Methods: 20 patients with allergic rhinitis(experiment group) and 20 patients without allergic rhinitis(comparison group) were selected.The peripheric serum levels of interleukin-2,interleukin-4 and inter leukin-12 were detected by ELISA method in two groups. Results: The level of IL-2,IL-12 in experiment group were lower than comparison group(P<0.05),While the level of IL-4 were higher in experiment group(P<0.05).And all the difference were significant. Conclusion: IL-2,IL-4 and IL-12 may play an important role in the pathogenesis of allergic rhinitis and therapy of allergic rhinitis. |
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| Keywords: | interleukin-2 interleukin-4 interleukin-12 allergic rhinitis |
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