| IL-8与胃癌细胞SGC7901MMP-2和MMP-9表达的关系 |
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| 引用本文： | 林晓,王娅兰. IL-8与胃癌细胞SGC7901MMP-2和MMP-9表达的关系[J]. 重庆医学, 2005, 34(11): 1657-1658,1661 |
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| 作者姓名： | 林晓 王娅兰 |
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| 作者单位： | 重庆医科大学基础医学院病理教研室,400016;重庆医科大学基础医学院病理教研室,400016 |
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| 摘 要： | 目的探讨趋化因子白介素-8（IL-8）与胃癌细胞SGC7901细胞胶原酶MMP-2和MMP-9表达的关系.方法体外细胞培养,MTT法及免疫组化方法检测细胞增殖率及MMP-2,MMP-9蛋白表达.结果 IL-8处理组SGC7901细胞MMP-2表达较对照组（无IL-8）比较,具有显著增强（P〈0.05）,而MMP-9无明显差异.结论 IL-8能促进细胞SGC7901 MMP-2表达,而对MMP-9无明显影响.
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| 关 键 词： | SGC7901 白介素-8 MMP-2 MMP-9 细胞培养 免疫组织化学 |
| 文章编号： | 1671-8348（2005）11-1657-03 |
Relationship of MMP-2 and MMP-9 expression of SGC7901 with IL-8 in vitro |
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| LIN Xiao,WANG Ya-lan. Relationship of MMP-2 and MMP-9 expression of SGC7901 with IL-8 in vitro[J]. Chongqing Medical Journal, 2005, 34(11): 1657-1658,1661 |
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| Authors: | LIN Xiao WANG Ya-lan |
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| Affiliation: | Department of Pathology ,College of Basic Medicine ,Chongqing University of Medical sciences ,Chongqing 400016 ,China |
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| Abstract: | Objective To study the effect of expression of MMP-2 and MMP-9 in gastric cancer cell line SGC7901 with IL-8 in vitro.Methods The proliferative activity was determined by MTT assay.MMP-2 and MMP-9 expression was detected by immunohistochemistry.Results Cultured with IL-8 for 72h,MMP-2 expression of SGC7901 was more than that of control group.(P<(0.05)).Conclusion The data suggest that IL-8 can increase expression of MMP-2 protein of SGC7901. |
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| Keywords: | SGC7901 MMP-2 MMP-9 |
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