The leading role of membrane Ca(2+)-ATPase in recovery of Ca(2+) homeostasis after glutamate shock |
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Authors: | Storozhevykh T P Pinelis V G Vinskaya N P Surin A M Khodorov B I |
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Affiliation: | (1) Laboratory of Membranology, Research Center of Children Health, Russian Academy of Medical Sciences, Russia;(2) Russian Academy of Medical Sciences, Institute of General Pathology and Pathological Physiology, Moscow |
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Abstract: | Combined blockade of Na+/Ca2+ exchange, Ca2+ uptake by mitochondria and endoplasmic reticulum usually does not prevent recovery of the basal level of intracellular Ca2+ after 1-min action of glutamate (100 M) or K+ (50 mM). However, replacement of Ca2+ with Ba2+, which cannot be transported by Ca2+-ATPase, considerably delayed the decrease in intracellular Ba2+ after its rise caused by glutamate or potassium application in all examined cells, which attest to an important role of Ca2+-ATPase in Ca2+ extrusion after the action of glutamate or K+. |
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Keywords: | neuron glutamate neurotoxicity Ca2+-ATPase Na+/Ca2+-exchange |
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