Urease-Based Mucosal Immunization against Helicobacter heilmannii Infection Induces Corpus Atrophy in Mice |
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| Authors: | Christine Dieterich, Hanifa Bouzour ne, Andr L. Blum, Ir ne E. Corth sy-Theulaz |
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| Affiliation: | Division of Gastroenterology, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland. |
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| Abstract: | Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage. |
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