碱化利多卡因在剖腹产中母婴血药浓度的研究

３０例ＡＳＡⅠ￣Ⅱ级的择期剖腹产产妇随机分为对照组（Ａ组）和碱化利多卡因组（Ｂ组），每组１５例，用１．６％利多卡因（ｐＨ为４．４６）和１．６％碱化利多卡因（ｐＨ为７．０１）行硬膜外阻滞，按计划取产妇静脉血和新生儿脐血，应用荧光偏振免疫法测定利多卡因的血液浓度。结果在和药量无显著性差异的情况下，Ａ、Ｂ两组产妇和新生儿血液利多卡因浓度无显著性差异（Ｐ〉０．０５），新生儿１￣５ｍｉｎ Ａｐｇａｒ评分两组

The Study of Alkalized Lidocaine Serum Concentration in Mothers and Their Infants in Caesarean Section

Thirty ASA I-III grade lying in women receiving elective caesarean birth's operation during eqidural anesthesia were randomly divided into two groups. The group A (contrasting group ) received 1.6% lidocaine(pH=4.46). The group B received 1.6% alkalized lidocaine(pH=7 01). Drawing the blood in lying-in women's veins and infants babies'umbilical cords, we determined the concentration of lidocaine in blood by immunofluorescence. The results showed that, when there were not markable difference in dose of giving medicine, lidocaine serum concentration between group A and B were not markable( P >0.05), lowing from lying-in women and their infant babies. The Apgar score from the first to the fifth second were all above eight marks, without obvious difference. The lidocaine, using in group B, took effect more quickly than that in group A( P <0.05). It was regarded that alkalized lidocaine can be used in caesarean birth's operations with advantages such as taking effect quickly, having a sound effect and having no byproduct on patients under routine dose.