泌尿生殖道支原体感染及耐药性研究

目的探讨泌尿生殖道支原体感染趋势及耐药性，指导临床合理用药。方法采用blycoplasma IST试剂盒对478例疑似非淋菌性尿道（宫颈）炎患者的泌尿生殖道标本进行支原体培养、鉴定和药敏检测。结果支原体培养总阳性率为43．51％（208／478），其中解脲脲原体（the）为36．82％（176／478），显著高于人型支原体（Mh）1．67％（8／478）和Uu＋Mh混合感染5．02％（24／478）（P〈0．01）；女性患者支原体检出率55．05％（158／287），显著高于男性患者检出率26．18％（50／191），（P〈0．01）；208例患者支原体对6种抗生素敏感性依次为原始霉素（99．04％）、强力霉素（91．83％）、交沙霉素（88．94％）、四环素（75．00％）、氧氟沙星（38．94％）、和红霉素（14．42％）。结论支原体是引起泌尿生殖道感染的主要病原体之一；其感染率女性高于男性；监测支原体的耐药性对指导临床治疗具有重要意。

Study on Mycoplasma infection in genitourinary tract and its antibiotic resistance

Objective To investigate the infection trends and drug resistance of Mycoplasma from the urogenital tract for the guidance of rational use of antibiotics in clinical practice.Methods Mycoplasma-cultures,identifies and drug sensitive tests with the use of IST kit were conducted in specimens from urogenital tract of 478 nongonococcal urethritis(NGU) patients.Results 43.51% of the cases(218/478)were positive in the Mycoplasma culture,36.82%(176/478),1.67%(8/478) and 5.02%(24/478) for Ureaplasma urealyticum(Uu),Mycoplasma hominis(Mh) and Uu Mh respectively.The positive rate of Uu was significantly higher than of Mh or Uu Mh(P<0.01).The female positive rate of Mycoplasma was 55.05%(158/287) and the male 26.18%(50/191)(P<0.01).The sensitivity of Mycoplasma to antibiotics was as follows from high to low Pristinamycine(99.04%),Doxycycline(91.83%),Josamycin(88.94%),Tetracycline(75.00%),Ofloxacin(38.94%) and Erythromycin(14.42%).Conclusion Mycoplasma is one of major pathologenic agent of urogenital infection.The infection percentage of Mycoplasma is higher in the female than in the male.Monitoring drug resistance of Mycoplasma is of great imprtan.