MTHFR C667T多态性与先兆子痫易感性的荟萃分析

目的探讨MTHFRC667T基因多态性对先兆子痫(PE)易感性的影响。方法检索CBMdisc、Pubmed等数据库,按纳入标准纳入有关MTHFRC667T基因多态性与PE的病例对照研究进行荟萃分析。结果共纳入24篇文献(26个病例对照研究),共计PE患者3017例,对照者4910例。研究分析显示MTHFRC667T基因多态性与PE存在明显关联[基因频率对比的OR(95%CI)=1.17(1.05～1.30),POR=0.006;隐性遗传对比模型的OR(95%CI)=1.18(1.01～1.38),POR=0.047;显性遗传对比模型的OR(95%CI)=1.20(1.08～1.34),POR=0.001;纯合子对比模型的OR(95%CI)=1.27(1.07～1.52),POR=0.008]。亚组分析显示,MTHFRC667T基因多态性与PE在亚洲人种中存在明显关联,但在欧洲人群及非洲分群中不存在明显关联。结论 MTHFRC667T多态性与PE易感性存在明显关联,但这种关联关系存在明显人种差异。

MTHFR C667T Polymorphism and Preeclampsia Risk: A Meta-analysis

Objective To approach the effect of MTHFR C667T polymorphism on the risk of preeclampsia( PE) . Methods Searches of the published literature were conducted in PubMed and CBM databases. All eligible studies about the association between MTHFR C667T polymorphism and PE risk were included according to the inclusion criterion. Results 24 original papers( 26 case-control individual stud- ies) were included in this Meta-analysis,including a total of 3017 cases and 4910 control. The results indi- cated that MTHFR C667T polymorphism was significantly associated with PE risk[T vs. C: OR( 95% CI) = 1. 17( 1. 05-1. 30) ,POR = 0. 006; Recessive model: OR( 95% CI) = 1. 18( 1. 01-1. 38) ,POR = 0. 047; Dominant model: OR( 95% CI) = 1. 20( 1. 08-1. 34) ,POR = 0. 001; Homozygote model: OR( 95% CI) = 1. 27( 1. 07-1. 52) ,POR = 0. 008]. Subgroup analyses based on ethnicity showed that the associa- tion was significant in Asians,but not in Caucasians and Africans. Conclusion MTHFR C667T polymorphism is associated with PE risk,but the association differs obviously among different ethnical groups.