甲真菌病的组织病理诊断研究

目的 探讨组织病理学方法在甲真菌病诊断中的意义，了解甲真菌感染的超微结构。方法 对临床拟诊为甲真菌病的６７例病甲分别采用直接镜检、真菌培养及组织病理学方法进行对比研究，同时选５例病甲做扫描电镜观察。结果 三种甲真菌检查方法的阳性率分别为６７．２％、４４．８％和８２．１％，扫描电镜在３个甲面均检出真菌成分。结论 组织病理学方法较传统的真菌镜检和培养更敏感（Ｐ均〈０．０１），两者结合可提高甲真菌病的正

Studies on histopathologic diagnosis of onychomycosis

Objective To study the value of histopathologic examination in the diagnosis of onychomycosis and to find out the ultrastructural pattern of the fungi in infected nails.Methods Sixty seven cases suspected onychomycosis were examined with histopathologic method and compared with mycologic examinations.Affected nails from 5 patients were observed under scanning electron microscopy (SEM).Results The positive rates of 3 methods were 67.2%,44.8%, 82.1% respectively.Fungal elements were seen in 3 parts of the affected nails under SEM.Conclusions Histopathologic method has a higher positive rate than mycologic examination ( P <0.01) in diagnosis of onychomycosis and diagnostic accuracy can be increased with the combination of both methods.