Studies on Thrombopoiesis. I. A Factor in Normal Human Plasma Required for Platelet Production; Chronic Thrombocytopenia Due to its Deficiency |
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| Authors: | SCHULMAN, IRVING PIERCE, MILA LUKENS, ABBY CURRIMBHOY, ZINET |
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| Affiliation: | 1 Children’s Memorial Hospital and the Departments of Pediatrics, NorthwesternUniversity Medical School, and The University of Chicago, Chicago, Ill.
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| Abstract: | 1. A case of chronic thrombocytopenic purpura has been presented inwhich the pathogenesis appears to be due to congenital deficiency of aplatelet-stimulating factor.2. The factor exists in normal plasma and is stable on storage under normalblood banking conditions and on freezing.3. The factor appears to act by stimulating megakaryocyte maturation andplatelet production in an orderly and sequential manner. Submitted on August 15, 1959 Accepted on October 9, 1959 |
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