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Invasive Rasamsonia argillacea infection in chronic granulomatous disease: Report of a new case and literature review
Affiliation:1. Global Action Fund for Fungal Infections (GAFFI), Geneva, Switzerland;2. Univ Rennes, CHU, Inserm, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, F-35000 Rennes, France;3. Société Française de Mycologie Médicale (SFMM), Paris, France;4. Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom;1. Programa de Pós-graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Brazil;2. Experimental Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;3. Microbiology Unit, Hospital de Clínicas de Porto Alegre, Brazil;4. Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Brazil
Abstract:Invasive Rasamsonia spp. infections are rare and usually associated with chronic granulomatous disease (CGD). We present a case of pulmonary and possible cerebral infection due to Rasamsonia argillacea in a girl with CGD receiving no primary antifungal prophylaxis. There was a fatal outcome despite the combination of antifungal therapy and surgical interventions. We also conducted a literature review on reported invasive Rasamsonia spp. infections in the setting of CGD.
Keywords:Chronic granulomatous disease  Invasive fungal infections
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